The secondary outcome was in-hospital death during that hospitalization for severe cutaneous adverse reaction.
In the crude analysis, age, comorbidity index score, and any use of diuretics were significantly associated with a severe cutaneous adverse reaction.
CHICAGO - Severe cutaneous adverse reactions requiring hospitalization occurred in 45 of 90,358 patients who began allopurinol treatment within a specified time period, for an incidence rate of 0.
The standardized incidence rate of Hospitalization for severe cutaneous adverse reactions was 0.
The hazard rate for severe cutaneous adverse reactions with allopurinol was 21.
The bulk of the severe cutaneous adverse reactions, 20 of the 45 cases, occurred within the first 30 days of treatment (incidence rate, 2.
NESINA, KAZANO, and OSENI are contraindicated in patients with a history of serious hypersensitivity reaction to any of the components of these products, such as anaphylaxis, angioedema, or severe cutaneous adverse reactions.
Hypersensitivity: There have been postmarketing reports of serious hypersensitivity reactions in patients treated with alogliptin such as anaphylaxis, angioedema or severe cutaneous adverse reactions.