severe combined immunodeficiency disorder


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Related to severe combined immunodeficiency disorder: SCID, trimethylaminuria

severe combined immunodeficiency disorder (SCID)

A congenital immunodeficiency of both T and B LYMPHOCYTES. The condition is due to a genetic defect that causes a lack of the intracellular enzyme adenosine deaminase. As a result neither of these classes of lymphocytes can become immunologically functional and the affected child is gravely susceptible to infections of all kinds. X-linked SCID (SCID-X1) has now been successfully treated by gene therapy.
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Preliminary results from an ongoing, multicenter study of X-linked Severe Combined Immunodeficiency Disorder (XSCID) suggest that gene therapy developed at Memphis, Tennessee-based St.
The condition - Severe Combined Immunodeficiency Disorder (SCID), which only affects boys - was spotted by the intensive care unit's Dr Helen Fardy, who organised further treatment at London's Great Ormond Street Hospital for Children.
If so, it will be the first time British doctors have successfully corrected the gene defect that causes Severe Combined Immunodeficiency Disorder (SCID).

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