chronic sclerosing sialadenitis

(redirected from severe chronic sclerosing sialadenitis)

chronic sclerosing sialadenitis

An uncommon unilateral inflammatory condition affecting the submandibular gland, which may mimic neoplasia.
 
Aetiology
Idiopathic, stones, microliths, infection, immune-related, linked to reduced salivary flow, increased viscosity. Long-standing obstruction causes inflammation leading to acinar atrophy and fibrosis. The most extreme manifestation of this process is the so-called Kuttner tumour—a rock-hard, tumour-like areas of end-stage fibrosis and lymphoplasmacytic inflammation, which may be accompanied by metaplasia (squamous, mucous, ciliated, oncocytic) in the ducts.

DiffDx
Lymphoma, lymphoepithelial lesion.
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