severe and complicated malaria

severe and complicated malaria

A malignant clinical form of Plasmodium falciparum infection, which is usually caused by a result of delay in treatment.

Clinical features
• A change in behaviour, confusion or drowsiness;
• Impaired consciousness or unarousable coma;
• Multiple/recurrent convulsion;
• Deep breathing or respiratory distress;
• Difficulty in breathing or demonstrable pulmonary oedema, as may be seen radiologically;
• Circulatory collapse or shock ;
• Jaundice;
• Haemoglobinuria;
• Bleeding tendency;
• Prostration (i.e, generalised weakness so the patient cannot walk or sit up without assistance);
• Severe anaemia with or without congestive cardiac failure.
References in periodicals archive ?
Severe and complicated malaria treated with artemisinin, artesunate or artemether in Viet Nam.
Management of severe and complicated malaria in the intensive care unit.
Association of HIV infection with the development of severe and complicated malaria cases at a rural hospital in Zimbabwe.
Each year, malaria directly causes nearly one million deaths and about 500 million clinical cases, of which 2 to 3 million constitute severe and complicated malaria (3,4).
While patients with uncomplicated malaria usually present with fever and non-specific symptoms, severe and complicated malaria is characterised by multiorgan involvement including acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) (8-10).
Observations from these studies and other published reports (11,12) suggest that about 5% patients with uncomplicated falciparum malaria and 20% -30% patients with severe and complicated malaria requiring ICU admission may develop ARDS.
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