severe acute respiratory syndrome


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

severe acute respiratory syndrome

 (SARS)
an infectious respiratory illness caused by a coronavirus and characterized by fever, dry cough, and breathing difficulties, often accompanied by headache and body aches.

severe acute respiratory syndrome (SARS),

SARS is a relatively recently diagnosed disorder that usually begins with a fever often accompanied by other symptoms such as headache, malaise, myalgia, or diarrhea. Following this prodrome by approximately 3-7 days, the patient develops cough (not usually productive) and shortness of breath. Abnormalities in laboratory findings may include leukopenia, thrombocytopenia, and elevated levels of creatinine phosphokinase or transaminases. Chest x-ray findings vary from normal or near-normal to the classic alveolointerstitial pattern seen in ARDS. Both interstitial and alveolar infiltrates have been described. Because at present no specific test for SARS exists and the definition is quite broad, SARS is usually considered a diagnosis of exclusion. Cases have been found in over two dozen countries and the case-fatality rate has been under 10% as of this writing, well below the initially feared levels of lethality. Transmission is considered to be person-to-person and probably chiefly by droplet spread. The incubation period is 2-7 days. Most available evidence points to coronaviruses as the etiologic agents. The coronavirus heretofore had been considered mainly a causative agent of the common cold.

severe acute respiratory syndrome (SARS),

SARS is a relatively recently diagnosed disorder that usually begins with a fever often accompanied by other symptoms such as headache, malaise, myalgia, or diarrhea. Following this prodrome by approximately 3-7 days, the patient develops cough (not usually productive) and shortness of breath. Abnormalities in laboratory findings may include leukopenia, thrombocytopenia, and elevated levels of creatinine phosphokinase or transaminases. Chest x-ray findings vary from normal or near-normal to the classic alveolointerstitial pattern seen in ARDS. Both interstitial and alveolar infiltrates have been described. Because at present no specific test for SARS exists and the definition is quite broad, SARS is usually considered a diagnosis of exclusion. Cases have been found in over two dozen countries and the case-fatality rate has been under 10% as of this writing, well below the initially feared levels of lethality. Transmission is considered to be person-to-person and probably chiefly by droplet spread. The incubation period is 2-7 days. Most available evidence points to coronaviruses as the etiologic agents. The coronavirus heretofore had been considered mainly a causative agent of the common cold.

severe acute respiratory syndrome

n.
SARS.

severe acute respiratory syndrome (SARS)

an infectious respiratory illness first reported in Asia and characterized by fever over 38° C (100.4° F), dry cough, and breathing difficulties, often accompanied by headache and body aches. It is believed to be caused by a strain of coronavirus, and severity ranges from mild illness to death. The infection appears to be spread by close contact with infected individuals, by inhalation of droplet nuclei containing the organism, or by contact with infected body fluids.
observations The incubation period appears to range from 2 to 10 days. Early signs are rapid onset of fever (greater than 38° C or 100.4° F), headache, chills, rigors, and achiness. Upper respiratory symptoms (e.g., runny nose and sore throat) are unlikely. After a period of 3 to 7 days, lower respiratory symptoms, such as shortness of breath and a dry cough, develop. Nausea, vomiting, and diarrhea are seen in about 25% of cases. In the next 7 days, mild cases show an abatement of symptoms; about 20% of patients show a progressive respiratory deterioration with severe dyspnea, hypoxemia, and ARDS. More than half of these patients require mechanical ventilation. Patients with progressive deterioration are at high risk of respiratory failure and death. High initial levels of lactate dehydrogenase and absolute neutrophil counts and an age greater than 60 years appear to be predictors of severe disease and death. Diagnosis is made using clinical exam and clinical history using criteria established by the CDC.
Early illness: Presence of two or more of the following features: fever (might be subjective), chills, rigors, myalgia, headache, diarrhea, sore throat, or rhinorrhea.
Mild to moderate illness: History of fever equal to 38° C (100.4° F) and one or more symptoms of lower respiratory tract illness (cough, dyspnea, and shortness of breath).
Severe illness: Radiographic evidence of pulmonary infiltrates or ARDS or autopsy findings consistent with pathological conditions of pneumonia or ARDS without identifiable cause and no alternative diagnosis.
Possible exposure: Travel to location with recent transmission of SARS up to 10 days before symptom appearance and/or close contact with a person with respiratory illness and history of travel.
Likely exposure: Close contact with person with confirmed SARS and/or close contact with a person with respiratory illness for whom a chain of transmission can be linked to a confirmed case of SARS 10 days before appearance of symptoms. Laboratory tests to detect SARS-CoV are being refined so lab criteria are changing. The following are general criteria for lab confirmation: detection of serum antibody to SARS-CoV by a test validated by CDC (e.g., enzyme immunoassay), or isolation in cell culture of SARS-CoV, or detection of SARS-CoV RNA by a reverse transcription polymerase chain reaction test validated by CDC and confirmed in a reference laboratory.
interventions Immediate isolation (droplet, contact, and respiratory) is required for anyone suspected of having SARS. All suspected cases should be reported to the local public health authorities/state health department and the CDC. Treatment is largely supportive and includes rest, humidification, hydration, nutritional support, and oxygen. Analgesics are used for pain. Tracheostomy and/or mechanical ventilation may be indicated to improve respiratory function. There are indications that pulsed steroids may shorten course of disease. In vitro tests are being conducted with interferon and have shown promise. Various vaccines are currently being developed and tested in animal and human trials.
nursing considerations Nursing is aimed at maintaining respiratory function, hydration, and nutritional status and containing the disease. Vigilance is necessary to monitor for early signs or symptoms among persons in close contact with SARS cases. Education is focused on isolation procedures for patients, family, and staff.

se·vere a·cute res·pi·ra·tory syn·drome

(SARS) (sĕ-vēr' ă-kyūt' res'pir-ă-tōr-ē sin'drōm)
Highly contagious, severe febrile respiratory illness caused by a coronavirus (SARS-CoV).

se·vere a·cute res·pi·ra·tory syn·drome

(SARS) (sĕ-vēr' ă-kyūt' res'pir-ă-tōr-ē sin'drōm)
Disorder that usually begins with a fever often accompanied by other symptoms such as headache, malaise, myalgia, or diarrhea. Following this prodrome by approximately 3-7 days, the patient develops cough (not usually productive) and shortness of breath.
References in periodicals archive ?
Devise corrective measures for pipeline projects by understanding Severe Acute Respiratory Syndrome (SARS) Coronavirus Infection pipeline depth and focus of Indication therapeutics.
Consensus document on the epidemiology of severe acute respiratory syndrome (SARS).
For severe acute respiratory syndrome (SARS), the required lag would be on the order of 15 days (95th percentile of the distribution of the generation interval described by Lipsitch et al.
In Los Angeles County, health officials have identified seven suspected cases of severe acute respiratory syndrome - six of them among travelers who had visited at least one nation where there have been deaths from the mystery flulike illness.
Nasdaq:AVII), today announced the publication of an article describing preclinical studies in which its NEUGENE(R) antisense compounds were used to inhibit infection by the severe acute respiratory syndrome coronavirus (SARS-CoV).
In a study of quarantine implementation in the greater Toronto area during its 2003 outbreak of severe acute respiratory syndrome (SARS) (1), investigators identified several factors that influenced compliance with quarantine restrictions (with rare exceptions, identified contacts of SARS patients in the area were quarantined in their own homes).
Initial tests have given clues to the identity of the pathogen involved in the infection, which health officials have dubbed severe acute respiratory syndrome (SARS).
What distinguishes this book from the surfeit of recent books hyping the threat of bioterrorism are its balanced perspective and elucidation of naturally emerging disease threats, such as severe acute respiratory syndrome (SARS) or West Nile virus, as exotic entities requiring a rapid and effective response; Mother Nature is quite the bioterrorist herself.
The Association has expressed interest in utilization of combined Ultraviolet and advanced air filtration technology aboard aircraft to control airborne infectious diseases since the Severe Acute Respiratory Syndrome (SARS) virus outbreak in early 2003 and recently the outbreak of the Bird Flu virus.
Multicentre Collaborative Network for Severe Acute Respiratory Syndrome (SARS) Diagnosis.
During BioFusion, dozens of presentations and workshops addressed pressing topics such as Severe Acute Respiratory Syndrome (SARS), HIV and other infectious diseases.
In 2003, human coronaviruses received worldwide attention with the emergence of severe acute respiratory syndrome (SARS) caused by a novel coronavirus (SARS-CoV).

Full browser ?