serum protein electrophoresis


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serum protein electrophoresis

A method for determining protein homeostasis in the body. Serum proteins are divided into prealbumin/albumin, alpha1, alpha2, beta and gamma zones; regions of the SPEP are increased or decreased in specific conditions, or vary according to gene polymorphisms.

serum protein electrophoresis

A method for determining protein 'homeostasis'; serum proteins are divided into prealbumin/albumin, α1 and α2, β, and γ zones; regions of the SPEP are ↑ or ↓ in certain conditions, or variable with gene polymorphisms
Serum protein electrophoresis
Fraction   Clinical conditions
Normal–6.5-8.0 g/dL 
↑ Dehydration, vomiting, diarrhea, myeloma, respiratory distress syndrome
↓ Burns, cancer–GI tract, liver disease, malnutrition, malabsorption, renal failure, ulcerative colitis
↓ Prealbumin ↓ Functional hepatic mass, inflammation, malnutrition
Albumin–4.0-6.0 g/dL 
↑ Dehydration, exercise
  Burns, cancer–GI tract, CHF, eclampsia, ↑ extracellular volume, inflammation, liver disease, malignancy, malnutrition, malabsorption, nephrotic syndrome, renal failure, SLE, ulcerative colitis
α1 –0.1-0.5 g/dL 
↑ antitrypsin  Inflammation, hepatocellular injury, malignancy, pregnancy, necrosis
↓ antitrypsin  Deficient allelle causing emphysema
± antitrypsin  Polymorphism of α1antitrypsin
α2 –0.4-1.0 g/dL 
↑ macroglobulin Biliary cirrhosis, burns, malignancy, inflammation, acute MI, nephrotic syndrome, rheumatic fever, selective proteinuria in age extremes
↑ haptoglobulin Inflammation
↓ haptoglobulin Hemolysis, hepatosplenic sequestration, liver disease
Total β–0.3-1.2 g/dL 
β1  
↑ transferrin Iron deficiency, estrogens
↓ transferrin Malnutrition, burns, inflammation
↓ lipoprotein  Hypercholesterolemia
±   Polymorphisms of transferrin
β2
↑ C3  Chronic inflammation, bile obstruction
↑ IgA  Malignancy, infection of mucosal surfaces, rheumatoid arthritis, ethanol, cirrhosis
↓ C3  Complement activation
± C3  Polymorphism of C3
γ–0.4-1.0 g/dL 
↑ Collagen vascular disease, inflammation, monoclonal antibody production, polyclonal stimulation, SLE
↓ Hypogammaglobulinemia, nephrotic syndrome
References in periodicals archive ?
19) Methodologies for serum protein electrophoresis in avian species have changed in recent years.
Twelve hours after presentation, an additional blood sample was obtained from the medial metatarsal vein for repeat CBC, plasma biochemical analysis (Table 1), serum protein electrophoresis (SPE), prothrombin time (PT), and activated partial thromboplastin time (aPTT).
Serum protein electrophoresis revealed a normal albumin level of 37 g/L (rr 30-48 g/L); normal [[Alpha.
The aim of this study was to evaluate results of serum protein electrophoresis (SPE) in falcons commonly used in falconry in the Middle East, to develop reference intervals, and to examine the diagnostic validity in cases of aspergillosis.
Serum protein electrophoresis (SPEP) was performed on the SPIFE 3000 electrophoresis analyzer (Helena Laboratories); this agarose gel system is not high resolution and visualizes a single (5 band.
The attending pathologist noted the discrepancy between the presence of a monoclonal band by serum protein electrophoresis and the patient's quantitative immunoglobulin measurements.
Her serum protein electrophoresis was remarkable for hypogammaglobulinemia [IgG 563 mg/dL (reference interval 600-1600 mg/dL), IgA 73 mg/dL (40-375 mg/dL), IgM 17 mg/dL (30-190 mg/dL)].
The serum protein electrophoresis pattern (SPEP) (2) for an 82-year-old female patient with known monoclonal gammopathy of undetermined significance demonstrated 2 aberrant protein bands, one in the [alpha]2-[beta]1 interzone (Fig.
A 74-year-old woman with toxic nodular goiter, diabetes mellitus, depression, gastroesophageal reflux disease, and hypercholesterolemia had routine serum protein electrophoresis done for the first time.
As part of her evaluation, a serum protein electrophoresis test was ordered (Fig.
Serum protein electrophoresis revealed hypoproteinemia (65 g/L; reference interval, 68-73 g/L), associated with decreased [gamma] globulins (4 g/L; reference interval, 9-15 g/L) but without a detectable paraprotein band.