serum protein electrophoresis


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serum protein electrophoresis

A method for determining protein homeostasis in the body. Serum proteins are divided into prealbumin/albumin, alpha1, alpha2, beta and gamma zones; regions of the SPEP are increased or decreased in specific conditions, or vary according to gene polymorphisms.

serum protein electrophoresis

A method for determining protein 'homeostasis'; serum proteins are divided into prealbumin/albumin, α1 and α2, β, and γ zones; regions of the SPEP are ↑ or ↓ in certain conditions, or variable with gene polymorphisms
Serum protein electrophoresis
Fraction   Clinical conditions
Normal–6.5-8.0 g/dL 
↑ Dehydration, vomiting, diarrhea, myeloma, respiratory distress syndrome
↓ Burns, cancer–GI tract, liver disease, malnutrition, malabsorption, renal failure, ulcerative colitis
↓ Prealbumin ↓ Functional hepatic mass, inflammation, malnutrition
Albumin–4.0-6.0 g/dL 
↑ Dehydration, exercise
  Burns, cancer–GI tract, CHF, eclampsia, ↑ extracellular volume, inflammation, liver disease, malignancy, malnutrition, malabsorption, nephrotic syndrome, renal failure, SLE, ulcerative colitis
α1 –0.1-0.5 g/dL 
↑ antitrypsin  Inflammation, hepatocellular injury, malignancy, pregnancy, necrosis
↓ antitrypsin  Deficient allelle causing emphysema
± antitrypsin  Polymorphism of α1antitrypsin
α2 –0.4-1.0 g/dL 
↑ macroglobulin Biliary cirrhosis, burns, malignancy, inflammation, acute MI, nephrotic syndrome, rheumatic fever, selective proteinuria in age extremes
↑ haptoglobulin Inflammation
↓ haptoglobulin Hemolysis, hepatosplenic sequestration, liver disease
Total β–0.3-1.2 g/dL 
β1  
↑ transferrin Iron deficiency, estrogens
↓ transferrin Malnutrition, burns, inflammation
↓ lipoprotein  Hypercholesterolemia
±   Polymorphisms of transferrin
β2
↑ C3  Chronic inflammation, bile obstruction
↑ IgA  Malignancy, infection of mucosal surfaces, rheumatoid arthritis, ethanol, cirrhosis
↓ C3  Complement activation
± C3  Polymorphism of C3
γ–0.4-1.0 g/dL 
↑ Collagen vascular disease, inflammation, monoclonal antibody production, polyclonal stimulation, SLE
↓ Hypogammaglobulinemia, nephrotic syndrome
References in periodicals archive ?
19) Methodologies for serum protein electrophoresis in avian species have changed in recent years.
Protein fractions vary significantly with age and the natural history of the individual and should be taken into consideration when assessing results of serum protein electrophoresis from whooping cranes, and likely other crane species.
Serum protein electrophoresis by CZE 2000 clinical capillary electrophoresis system.
Serum protein electrophoresis was performed on blood samples collected from 105 falcons that were submitted to the Dubai Falcon Hospital (Dubai, United Arab Emirates) between 2003 and 2006.
Usually, the biochemical exploration of an MM-associated pleural effusion includes measurement of the total protein in the pleural fluid, serum protein electrophoresis, and pleural fluid protein electrophoresis.
The serum protein electrophoresis had been performed by capillary electrophoresis, a technique in which radiocontrast dyes and antibiotics can create spikes that mimic an M protein (1-5).
Detection by immunofixation of M proteins in hypogammaglobulinemic patients with normal serum protein electrophoresis results.
In addition to a small or absent M-spike on serum protein electrophoresis, laboratory findings that differentiate IgD myeloma from the more common IgG and IgA myelomas include the presence of a [lambda] light chain predominance, as seen in our case, and higher rates of Bence Jones proteinuria (5, 7).
The [kappa]-FLC concentration estimated by serum protein electrophoresis was 4-6 g/L.
1] Nonstandard abbreviations: sFLC, serum free light chain; SPE, serum protein electrophoresis.
Moreover, we did indicate in our report that cryocrit does not differentiate type 1 and type 2 cryoglobulinemia, and we recommended that serum protein electrophoresis and immunofixation should be conducted on resolubilized cryoprecipitate (4).
Aggregation of serum free light chains (FLC) causes overestimation of FLC nephelometric results as compared to serum protein electrophoresis (SPE) while preserving clinical usefulness [Abstract].