serpin


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Related to serpin: Serine protease inhibitor, Serine proteinase inhibitors

serpin

 [ser´pin]
any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissues; all are similarly structured single-chain glycoproteins although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha1-antitrypsin, antithrombin III, α2-antiplasmin, C1 inhibitor, and plasminogen activator inhibitor 1 (PAI-1). Called also serine protease or proteinase inhibitor.

serpin

/ser·pin/ (ser´pin) any of a superfamily of inhibitors of serine proteinase, found in plasma and tissues; all are homologous single-chain glycoproteins targeting specific serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling.

serpin

[ser′pin]
any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissue. All are similarly structured single-chain glycoproteins, although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha1-antitrypsin, antithrombin III, alpha2-antiplasmin, C1 inhibitor, and plasminogen activator inhibitor 1. Also called serine protease inhibitor or serine proteinase inhibitor.

serpin

(ser′pĭn) [ ser(ine) + p(roteinase) + in(hibitor)]
A serine protease inhibitor.
References in periodicals archive ?
Target NCBI# Forward Heliomicin FJ546343 TGTCAACTACACCTCCGACTGCAA Virescein FJ546342 TTGTTGTGATTGCTCTGCTGGTGC Heliocin FJ546346 TGATCATCCGATCCTGCCTTCAGT Gloverin FJ546344 AACCGATGGAATGGTTCCAGGCT Hv-3-Tox FJ161976 TTTCCGAAATGCAGAAGGAGTGCC Serpin FJ577645 GCATCATCGGACCTGGCAATTGAT HvRPL4 EU523116 AGATGCTGAACGTGGACAAGCTGA Target Reverse Reference Heliomicin TCGCACCAACAGTTGCACTTAGCG This report Virescein CCGGAGTCCTTTGCCAATTGCTTT Bulet et al.
Whisstock, 1845-1894, 2000, Phylogeny of the serpin superfamily: implication of patterns of amino acid conservation for structure and function, 10 (12).
Discoordinate hormonal and ontogenetic regulation of four rat serpin genes.
AAT, FCG, and Serpin showed approximately 2 fold increase in ACS and UA samples as compared to controls at 6-12h.
Identification of centerin: a novel human germinal center B cell-restricted serpin.
Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system.
The major progesterone-modulated proteins secreted into the sheep uterus are members of the serpin superfamily of serine protease inhibitors.
M151R encodes Serp2, a serpin that specifically binds interleukin-1[beta]-converting enzyme (23) and is involved in the pathogenesis of myxomatosis (24).
Serpin A1, a secretory glycoprotein involved in the modulation of inflammatory responses, is also expressed in ALK+ ALCL and can inhibit granzyme B-mediated killing, thereby protecting tumor cells from cytotoxic T and NK cells; expression of serpin A1 correlates with metastases and extranodal disease.
confusa 1 AMMKAEVDEMLPGAA - ~720 chymotrypsin inhibitor Taeniopygia guttata 74 NMMKAEVDLYLPKLK 60 189 serine (or cysteine) protease inhibitor Bos taurus serpin 86 NMGKREVDLYLPRFK 40 394 peptidase inhibitor A.
Molecular and cellular aspects of the serpinopathies and disorders in serpin activity.
Madison has achieved an international reputation in the fields of serine protease and serpin basic research, and he is one of the lead inventors of Tenecteplase, an engineered protease therapeutic currently marketed by Genentech and Boehringer Ingelheim.