serpin

serpin /ser·pin/ (ser´pin) any of a superfamily of inhibitors of serine proteinase, found in plasma and tissues; all are homologous single-chain glycoproteins targeting specific serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling.

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serpin

[ser′pin]

any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissue. All are similarly structured single-chain glycoproteins, although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha₁-antitrypsin, antithrombin III, alpha₂-antiplasmin, C1 inhibitor, and plasminogen activator inhibitor 1. Also called serine protease inhibitor or serine proteinase inhibitor.

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serpin [ser´pin]

any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissues; all are similarly structured single-chain glycoproteins although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha₁-antitrypsin, antithrombin III, α₂-antiplasmin, C1 inhibitor, and plasminogen activator inhibitor 1 (PAI-1). Called also serine protease or proteinase inhibitor.