serotonin-selective reuptake inhibitor

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Selective serotonin reuptake inhibitor, serotonin reuptake inhibitor Pharmacology A class of antidepressants that slows reabsorption of serotonin by neurons; allowing it to remain in the synapse longer; SRIs should be started with ramped dosing Examples Buspirone, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, trazodone, venlaxfazine Indications Dysthymia or minor depression, atypical depression, anxiety Side effects Insomnia, agitation, headache, nausea, diarrhea, adverse interactions with other agents, especially fluoxetine Contraindications MAOIs. See Antidepressants, Obsessive-compulsive disorder.

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