serotonin syndrome


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serotonin syndrome

an aggregation of symptoms resulting from elevated levels of serotonin, usually due to ingestion of two or more drugs (for example, MAOIs, SSRIs) that interfere with serotonin metabolism at different points. Symptoms occur on a spectrum and may include agitation, confusion, diaphoresis, diarrhea, fever, shivering, tremor, myoclonus, rigidity, trismus, opisthonus, seizures, drowsiness, hallucinations, and coma. Autonomic signs include abdominal pain, diarrhea, flushing, hypertension, mydriasis, salivation, tachycardia, and tachypnea. Hyperthermia is common. More advanced cases may include patients suffering DIC, rhabdomyolysis, renal failure, respiratory failure, and ARDS.

serotonin syndrome

an aggregation of symptoms resulting from elevated levels of serotonin, usually due to ingestion of two or more drugs (for example, MAOIs, SSRIs) that interfere with serotonin metabolism at different points. Symptoms occur on a spectrum and may include agitation, confusion, diaphoresis, diarrhea, fever, shivering, tremor, myoclonus, rigidity, trismus, opisthonus, seizures, drowsiness, hallucinations, and coma. Autonomic signs include abdominal pain, diarrhea, flushing, hypertension, mydriasis, salivation, tachycardia, and tachypnea. Hyperthermia is common. More advanced cases may include patients suffering DIC, rhabdomyolysis, renal failure, respiratory failure, and ARDS.

serotonin syndrome

Psychiatry A potentially life threatening condition caused by combined therapy with MAOIs and selective serotonin reuptake inhibitor–SSRI, antidepressants–Prozac, Zoloft, Paxil, Luvox, Wellbutrin–bupropion, tryptophan or tricyclic antidepressants, which abruptly ↑ serotonin resulting in neuromuscular, autonomic, and behavioral changes due to ↑ CNS serotonin activity Clinical Confusion, diaphoresis, ataxia, excitement, hyperthermia, hyperreflexia, myoclonus, hypotension, tremor Complications DIC, rhabdomyolisis, cardiovascular compromise Management D/C offending drug, support vital functions, dantrolene–muscle relaxant, Periactin–cyproheptadine–antihistamine, serotonin antagonist. See MAOI, SSRI.

serotonin syndrome

A potentially dangerous reaction to drug administration or drug interactions that involve excessive serotonergic agonism. The effects range from mild to life-threatening and include AKATHISIA, tremor, altered mental states, agitation, clonus, muscular hypertonicity, hyperthermia and death. Many drugs have been found to be implicated and these are not limited to the selective serotonin re-uptake inhibitors.

Serotonin syndrome

A group of symptoms caused by severely elevated serotonin levels in the body.
References in periodicals archive ?
The development of potentially life-threatening serotonin syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions have been reported during use of serotonergic drugs, including, but not limited to, selective serotonin-norepinephrine reuptake inhibitors, and selective serotonin reuptake inhibitors, tricyclic antidepressants, bupropion, triptans, dietary supplements such as St.
Serotonin syndrome is a deadly threat and can have serious implications for the patient if one or more serotonin-augmenting drugs are being prescribed to these patients.
Bush also advised the emergency department staff to be aware of the symptoms of serotonin syndrome, which can occur when tramadol is taken in combination with some other drugs, including common antidepressants.
Another recent development is the FDA's announcement in May 2013 that an increased risk for serotonin syndrome in patients taking 5-H[T.
Joint pain and muscle spasms are among the symptoms of serotonin syndrome, a condition in which serotonin receptors become overstimulated due to a buildup of serotonergic drugs in the body.
In terms of side effects, seizure and serotonin syndrome - unusual side effects for the opioids but common for antidepressants - have been reported among patients using tramadol, especially when co-administered with TCAs and SSRIs.
Duloxetine and Escitalopram were held upon admission for concerns about serotonin syndrome.
The authors argue that the combination of a MAO inhibitor with another centrally active serotonergic agent poses significant health risks from MAO inhibitor poisoning or serotonin syndrome.
The hyperthermic complications of MDMA use are well known--exertional hyperpyrexia and serotonin syndrome, although the two may overlap.
Taking tramadol with other medications that increase serotonin levels, such as antidepressants, will increase the patient's risk of serotonin syndrome (Donnan & Ledger, 2006).
Traditional therapies focus on elevating serotonin levels, and can sometimes produce serious side effects such as a serotonin syndrome - often accompanied by hallucinations.

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