in the treatment of depressive and anxiety disorders.
TABLE Drug treatment options for anxiety or depression in COPD (18, 19) Drug class Indications and Contraindications and dosage cautions Antianxiety GAD: 15-30 mg/d Hypersensitivity to drug -buspirone q 8-12h Use with caution in renal or hepatic impairment TCAs MDD: Acute Ml recovery -amitriptyline 100-200 mg at -nortriptyline night 25 mg q 6-8h Hypersensitivity to drug class Avoid abrupt withdrawal Use with caution in hepatic impairment, prolonged QT interval, and coadministration with serotonergic drugs
(MAOI, linezolid, IV methylene blue) SSRI * MDD: Hypersensitivity to drug -sertraline 50-200 mg/d class Concomitant disulfram use Avoid abrupt withdrawal Use with caution in hepatic impairment SNRI * GAD: 37.
The development of a potentially life-threatening serotonin syndrome has been reported with SSRIs, including paroxetine, alone but particularly with concomitant use of serotonergic drugs
(including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St.
The statements advise that linezolid or methylene blue should "generally not be given" to patients on serotonergic drugs
The effects of serotonergic drugs
on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat.
For example, the combination of serotonergic drugs
with MDMA may potentially place users at risk for serotonin syndrome (Oesterheld et al.
Any antidepressant that increases serotonin may precipitate a rare but serious adverse event known as serotonin syndrome, which can be associated with monotherapy or combinations of serotonergic drugs
Dextromethorphan can cause serotonin syndrome when taken with serotonergic drugs
such as amphetamines, cocaine, monoamine oxidase inhibitors, or selective serotonin reuptake inhibitors.
Triptans, which are 5-hydroxytryptamine receptor agonists used to treat migraine; and SSRIs and SNRIs, used to treat depression and other mood disorders, are serotonergic drugs
The pharmacology of impulsive behaviour in rats VI: the effects of ethanol and selective serotonergic drugs
on response choice with varying delays of reinforcement.
It would seem essential that the large number of novel serotonergic drugs
currently under investigation be examined for treatment in Alzheimer-type dementia," Cross says.
If concomitant use of PRISTIQ with other serotonergic drugs
is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increase.