seronegative

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seronegative

 [se″ro-neg´ah-tiv]
showing negative results on serologic examination; showing a low level of antibody.

se·ro·neg·a·tive

(sē'rō-neg'ă-tiv),
Lacking an antibody of a specific type in serum; used to mean absence of previous infection with a specific agent (for example, rubella virus), disappearance of antibodies after treatment of a disease (for example, syphilis), or absence of antibody usually found in a given syndrome (for example, rheumatoid arthritis without rheumatoid factor).

seronegative

/se·ro·neg·a·tive/ (-neg´ah-tiv) showing negative results on serological examination; showing a lack of antibody.

seronegative

(sîr′ō-nĕg′ə-tĭv)
adj.
Indicating a negative reaction to a serological blood test, especially one testing for the presence of antibodies.

seronegative

[-neg′ətiv]
Etymology: L, serum, whey, negare, to deny
a serological test with negative results.

seronegative

Immunology The lack of antibodies or other immune markers in serum that would indicate exposure to a particular organism or antigen; in an immunocompetent person, exposure to an antigen results in a seroconversion and the subject is said to then be seropositive. Cf Seropositive.

se·ro·neg·a·tive

(sēr'ō-neg'ă-tiv)
Lacking an antibody of a specific type in serum; denoting absence of prior infection with a specific agent, disappearance of antibodies after treatment of a disease, or absence of antibody usually found in a given syndrome.

se·ro·neg·a·tive

(sēr'ō-neg'ă-tiv)
Lacking an antibody of a specific type in serum.

seronegative (sir´ōneg´ətiv),

n serologic evidence of the lack of an antibody of a specific type in the serum; diagnostically useful in ruling out Lyme disease, syphilis, human immunodeficiency virus (HIV), serum hepatitis B, and many other viral diseases.

seronegative

showing a negative serum reaction; i.e. an animal with no detectable serum antibodies to a specified microorganism.
References in periodicals archive ?
The highest seronegativity was seen in children between 12-23 months of age.
Seronegativity was found to decrease with the increasing number of OPV doses (Table I).
Although, there have been no polio cases due to wild poliovirus since 1998 in Turkey (13), the children are at the risk and vulnerable to polio because of high seronegativity.
Seronegativity in children was higher in urban areas than rural.
The percentage of seronegativity among the unvaccinated children was approximately two-fold higher than children who received four doses of vaccine.
Among 375 patients in ICU, 38 consecutive patients with septic shock were eligible, but 13 were excluded because of CMV seronegativity (n = 5), immunosuppressive therapy (n = 2), or ICU stay <7 days (n = 6).
Seronegativity was defined as absence of antibody in convalescent-phase serum obtained [greater than or equal to] 21 days after symptom onset (3).
A confirmed dengue case was required to be positive by either reverse transcription-polymerase reaction (3), or demonstrate seroconversion by dengue-specific immunoglobulin (Ig) M and seronegativity for Japanese encephalitis virus (JEV)-specific IgM by IgM-enzyme-linked immunosorbent assay (IgMELISA) (4).
Detection of an early nascent immune response remains difficult; this low early sensitivity may partially explain the 50% seronegativity rate in surveyed athletes, given the 10-day median duration between onset of fever and drawing of serum.
In two cases, in paired sera collected in 23-day intervals, a shift from 160 to seronegativity (titer [is less than] 10) was observed.
Totals do not match the text above because blood samples were not collected from captured rodents at sites B until October 1996 and because we included separately periods of seronegativity and seropositivity for deer mice that seroconverted.