The positive predictive value of combined serologic
testing in this small selected patient population was 100%.
When performed and interpreted in accordance with current guidelines, 2-tiered serologic
analysis has a sensitivity of [approximately equal to] 70%-100% and a specificity >95% for disseminated Lyme disease (Table) (6,12-15).
Among infants with reported outcomes, postvaccination serologic
testing data from Enhanced Perinatal Hepatitis B Case Management Projects indicated that timely postexposure prophylaxis might be 93% effective in protecting infants from perinatal hepatitis B infection.
surveillance provides a more stable method for predicting future disease incidence than does clinical surveillance, which captures only individuals who present with symptoms, said Dr.
Evaluations by a rheumatologist significantly affected diagnoses because of additional serologic
testing (such as a myositis panel) and because the rheumatologist was able to elicit subtle clues that are suggestive of a rheumatologic diagnosis.
We suggest checking serologic
titers for VZV antibody, followed by a VZV vaccination for nonimmune health care workers.
The only way to prevent or detect a higher proportion of infants with congenital infection is by systematic serologic
screening, they concluded, adding that cost analyses should be performed before any decision making occurs.
Repeat HIV serologic
testing showed a positive HIV enzyme immunoassay and a positive Western blot with bands at gp120, gp160, and p24.
7 weeks posttransplant-1 week before any serologic
changes occurred-34 of 35 patients with CMV were positive for late gene expression.
We used 3 definitions that would indicate a diagnosis of syphilis: 1) positive DFM results (5); 2) a combination of nontreponemal and/or treponemal tests as recommended by CDC (2) (if possible, samples that had negative results on a first nontreponemal assay underwent a second test to identify seroconversion ); and 3) an enhanced definition combining clinical information suggestive of syphilis and results from DFM and serologic
Surveillance efforts are complicated by ambiguous terminology and serologic
testing with antibody cross-reactivity.
Another notable limitation of using serologic
markers to diagnose celiac disease is poor sensitivity in patients with mild disease.