SRPK1

(redirected from serine/threonine-protein kinase SRPK1)

SRPK1

A gene on chromosome 6p21.31 that encodes a serine/arginine-rich protein kinase which phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides (RS domains). SRPK1 plays a role in phosphorylating SR splicing factors; it plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells, and reorganising nuclear speckles during mitosis.
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