The study investigators hypothesized that bile acid metabolism is altered in patients with type 2 diabetes which may contribute to the observed metabolic behavior, and further, that treatment with a bile acid sequestrant
(BAS) might normalize these alterations.
Colesevelam hydrochloride (cholestagel): a new, potent bile acid sequestrant
associated with a low incidence ofgastrointestinal side effects.
Alkaline cleaners are specifically formulated chemical blends consisting of alkaline salts, wetting agents, and sequestrant
15] Use of alternative curing systems involving an antioxidant/a sequestrant
to duplicate the action of nitrite was attempted.
The wide applicability of citric acid as an acidulant, preservative, emulsifier, flavorant, sequestrant
, and buffering agent in numerous products of food and non-food industries has led to its propelled growth, which is expected to continue in the forecast period.
9) Cholestyramine, a bile acid sequestrant
, and crushed gelatin-coated capsules, such as omeprazole, may also occlude nasogastric tubes.
An alternative for these patients is a bile acid sequestrant
It may also optionally contain a suspending agent, one sequestrant
, emollient, a basic pH modifier, fragrance, antimicrobial agent and preservative.
Colesevelam (Welchol), a bile acid sequestrant
, is the only agent approved by the Food and Drug Administration for both treatment of dyslipidemia and improving glycemic control in type 2 diabetes.
Despite the proved effectiveness of statin monotherapy for modifying the lipid profile, patients with severe dyslipidemias can benefit from the use of drug combinations such as a statin plus a bile acid sequestrant
, niacin, or a fibrate.
Combinations consisting of a statin and niacin are the most popular, but combinations of a statin and a fibrate or a statin and a bile acid sequestrant
are also used.
The statins, Vytorin and Zetia predominantly target LDL-C so patients with elevated triglycerides or decreased HDL even after treatment with one of these agents are often prescribed an add-on drug such as niacin, a fibrate, omega-3 fatty acid or bile acid sequestrant
to target these lipid abnormalities," said Decision Resources Analyst Christine Helliwell, Ph.