70,71] Treatment modalities included chemotherapy alone, neoadjuvant chemotherapy followed by cystectomy, cystectomy followed by adjuvant chemotherapy, cystectomy alone, transurethral resection of bladder tumour (TURBT) alone, radiotherapy alone and finally concurrent or sequential chemotherapy
5 percent of patients receiving sequential chemotherapy
It is generally accepted that patients with metastatic disease do benefit from systemic chemotherapy resulting in response rates of about 50% with combination chemotherapy, a median progression-free survival of about 9 months and a median overall survival approaching 2 years with the use of sequential chemotherapy
The 10-year overall survival rate of women who received sequential chemotherapy
followed by tamoxifen was 68%, compared with 62% with concurrent chemotherapy plus tamoxifen and 60% for tamoxifen alone.
Accrual to arm two was terminated mid-trial as an early survival analysis showed that this regimen would not demonstrate a survival improvement when compared with sequential chemotherapy
and radiation historical data.
Cell proliferation in malignant angioendothelioma during sequential chemotherapy
Other risk factors for febrile neutropenia included low pre-treatment levels of white blood cells and sequential chemotherapy
with adriamycin followed by cyclophsphamide, methotrexate and fluorouracil.
Juttner's experience in ex vivo stem cell expansion also provides additional strength for our work in optimized high dose sequential chemotherapy
Recently, Siefker-Radtke and colleagues presented data from a phase II randomized, 4-regimen selection trial of sequential chemotherapy
for patients with metastatic or unresectable urothelial cancer.