9-Sep

(redirected from septin 9)

9-Sep

A gene on chromosome 17q25 that encodes septin 9, a member of the septin family of nucleotide-binding proteins, which are required for cytokinesis, organisation of submembranous structures, neuronal polarity and vesicle trafficking. SEPT9 is a candidate for ovarian tumour suppressor gene.

Molecular pathology
SEPT9 mutations cause hereditary neuralgic amyotrophy (neuritis with brachial predilection). A translocation between SEPT9 and MLL on chromosome 11 results in acute myelomonocytic leukaemia.
References in periodicals archive ?
In this issue of Clinical Chemistry, Potter and colleagues describe a blood-based assay to detect ccfDNA methylated septin 9 (mSEPT9) and its ability to detect colon cancer (6).
The Septin 9 methylated DNA test measures if colorectal tumor DNA, which can be detected even in the earliest stages of colorectal cancer, is present in a patient's bloodstream.
Abbott offers a broad menu of tests on its m2000 system outside the United States including tests for HIV viral load, hepatitis B and C viral load, hepatitis C genotyping, chlamydia, gonorrhea, human papillomavirus, cytomegalovirus, Epstein-Barr virus, and methylated septin 9 (mS9) for colorectal cancer.
The program includes four 25-minute presentations given by speakers at the Institute's May 2009 Conference: Non-coding RNAs as Biomarkers in Human Cancers; From Discovery to the Clinic--The Novel DNA Methylation Biomarker, Septin 9, for the Detection of Colorectal Cancer in Blood; Cancer Biomarker Discovery in the Context of Individualized Medicine; and Metabolomics-derived Biochemical Markers of Prostate Cancer Aggressiveness.
With the data generated in the PRESEPT study, Epigenomics intends to demonstrate that colorectal cancer early detection with a blood test based on Septin 9 will meet the requirements of current U.
Plasma Septin 9 Testing," uses the results of the first study to compare the sensitivities of the stool DNA test and a plasma test for methylated Septin 9 (SEPT9) in identifying patients with large adenomas or colorectal cancer.
Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island.
In December 2009, Abbott Molecular introduced the first oncology assay on its m2000 system outside the United States - the Abbott RealTime mS9 Colorectal Cancer - that detects the methylated form of Septin 9, a gene linked to colorectal cancer, in blood specimens.
DES PLAINES, Illinois, January 6 /PRNewswire/ -- Abbott (NYSE: ABT) announced today it has received CE Marking (Conformite Europeene) in the European Union for a new molecular diagnostic test, Abbott RealTime mS9 Colorectal Cancer, a non-invasive DNA assay that detects the methylated form of Septin 9, a gene linked to colorectal cancer, in blood specimens.
SALT LAKE CITY -- ARUP Laboratories, a leading national clinical and anatomic pathology reference laboratory and a leader in innovative laboratory research and development, today announced it is offering the Septin 9 methylated DNA test, a new blood-based colorectal cancer screening method.
In December 2009, Abbott Molecular introduced the first oncology assay on its m2000 system - the Abbott RealTime mS9 Colorectal Cancer - that detects the methylated form of Septin 9, a gene linked to colorectal cancer, in blood specimens.