septin


Also found in: Wikipedia.

septin

A protein encoded on chromosome 16p11.1 that belongs to the septin family of GTPases, which are required for cytokinesis and maintaining cell morphology.

Molecular pathology
Septin 1 forms homo- and heterooligomeric filaments and may contribute to the neurofibrillary tangles in Alzheimer's disease.
References in periodicals archive ?
To circumvent this complexity, we will reconstitute cell-free actin networks and couple them to model biomembranes with the essential cellular linker protein septin.
2008) Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay.
These techniques exploit the polarization of light to follow cellular events, from the building of the mitotic spindle to the formation of septin structures, one molecule at a time.
sup][44] EGFR was recently shown to be activated by recurrent translocations in 7% of GBM samples: It was most frequently fused in-frame to septin 14 or phosphoserine phosphatase as the 3[acute accent] gene segment.
2] Human genes: EGFR, epidermal growth factor receptor; KRAS, kirsten rat sarcoma viral oncogene homolog; ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; EML4, echinoderm microtubule-associated protein like 4; ALK, anaplastic lymphoma receptor tyrosine kinase; SEPT9, septin 9; CDKN2A, cyclin-dependent kinase inhibitor 2A; MET, MET proto-oncogene, receptor tyrosine kinase; CDK6, cyclin-dependent kinase 6; BRAF, B-Raf proto-oncogene, serine/threonine kinase.
For example, detection of septin 9 (SEPT9) gene hypermethylation in the blood has been used in colorectal carcinoma screening whereas detection of glutathione S-transferase pi (GSTPi) gene hypermethylation in urine has been utilized as a prostate cancer biomarker [10-12].
Only order methylated septin (SEPT9) on patients for whom conventional diagnostics are not possible.
Sharma said that they found that the septin protein is a very strong regulator of the calcium response, which is essential for activating immune cells.
Other genes including BIRC5, an inhibitor of apoptosis; KIF4A, an ATP (adenosine triphosphate) dependent microtubule-based motor protein; and SEPT9, a member of the septin family involved in cytokinesis and cell cycle control, were upregulated and associated with poor prognosis.
PRESEPT is a multi-center, multi-national clinical study sponsored by Epigenomics prospectively evaluating the clinical performance of Epigenomics' proprietary biomarker, Septin 9, for colorectal cancer population wide screening of guideline-eligible individuals.