septin


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septin

A protein encoded on chromosome 16p11.1 that belongs to the septin family of GTPases, which are required for cytokinesis and maintaining cell morphology.

Molecular pathology
Septin 1 forms homo- and heterooligomeric filaments and may contribute to the neurofibrillary tangles in Alzheimer's disease.
References in periodicals archive ?
In this issue of Clinical Chemistry, Potter and colleagues describe a blood-based assay to detect ccfDNA methylated septin 9 (mSEPT9) and its ability to detect colon cancer (6).
Only order methylated septin (SEPT9) on patients for whom conventional diagnostics are not possible.
Sharma said that they found that the septin protein is a very strong regulator of the calcium response, which is essential for activating immune cells.
Other genes including BIRC5, an inhibitor of apoptosis; KIF4A, an ATP (adenosine triphosphate) dependent microtubule-based motor protein; and SEPT9, a member of the septin family involved in cytokinesis and cell cycle control, were upregulated and associated with poor prognosis.
Abbott offers a broad menu of tests on its m2000 system outside the United States including tests for HIV viral load, hepatitis B and C viral load, hepatitis C genotyping, chlamydia, gonorrhea, human papillomavirus, cytomegalovirus, Epstein-Barr virus, and methylated septin 9 (mS9) for colorectal cancer.
PRESEPT is a multi-center, multi-national clinical study sponsored by Epigenomics prospectively evaluating the clinical performance of Epigenomics' proprietary biomarker, Septin 9, for colorectal cancer population wide screening of guideline-eligible individuals.
The Rockefeller University laboratory of Hermann Steller created mice that lack the gene septin 4.
Plasma Septin 9 Testing," uses the results of the first study to compare the sensitivities of the stool DNA test and a plasma test for methylated Septin 9 (SEPT9) in identifying patients with large adenomas or colorectal cancer.
The septin gene family is a conserved set of guanosine-5'-triphosphatebinding proteins that function in vesicle trafficking, apoptosis, and cytoskeletal remodeling (20).
London, Dec 5 (ANI): Scientists have discovered a new defensive weapon, a cytoskeletal protein called septin, which is deployed by humans cells to cage the invading Shigella bacteria that causes potentially fatal human diarrhea.