sepsis syndrome


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sepsis syndrome

clinical evidence of acute infection with hyperthermia or hypothermia, tachycardia, tachypnea and evidence of inadequate organ function or perfusion manifested by at least one of the following: altered mental status, hypoxemia, acidosis, oliguria, or disseminated intravascular coagulation.

sepsis syndrome

clinical evidence of acute infection with hyperthermia or hypothermia, tachycardia, tachypnea and evidence of inadequate organ function or perfusion manifested by at least one of the following: altered mental status, hypoxemia, acidosis, oliguria, or disseminated intravascular coagulation.

sepsis syndrome

A constellation of signs, Sx, and systemic responses caused by a wide range of microorganisms that may eventuate into septic shock; SS is a systemic response to infection
Sepsis syndrome, defining parameters  
• Temperature Hypothermia < 35ºC–96ºF or hyperthermia > 39ºC–101ºF
• Tachycardia > 90 beats/minute
• Tachypnea > 20 breaths/minute
• Site of infection Clinically evident focus of infection or positive blood cultures
• Organ dysfunction 1+ end organs with either dysfunction or inadequate perfusion or cerebral dysfunction
• Metabolic derangement Hypoxia–PaO2 < 75 mm Hg, ↑ plasma lactate/unexplained metabolic acidosis
• Fluid imbalance Oliguria–< 30 mL/hr
• WBC counts < 2.0 x 109/L; > 12.0 x 109/L–US: < 2000/mm3; > 12 000/mm3
Note: The confusing semantics of the terms sepsis, sepsis/septic syndrome, and septic shock are unlikely to be resolved in the forseeable future; the terms sepsis and septic syndrome are essentially interchangeable and would in part overlap with septicemia–the early components of a pernicious infectious cascade that has spilled into the circulation; the term septic shock is used when the process becomes virtually irreversible.

sep·sis syn·drome

(sep'sis sin'drōm)
Clinical evidence of acute infection with hyperthermia or hypothermia, tachycardia, tachypnea, and evidence of inadequate organ function or perfusion manifested by at least one of the following: altered mental status, hypoxemia, acidosis, oliguria, or disseminated intravascular coagulation.

sep·sis syn·drome

(sep'sis sin'drōm)
Clinical evidence of acute infection with hyperthermia or hypothermia, tachycardia, tachypnea, and evidence of inadequate organ function.
References in periodicals archive ?
Endotoxemia and bacteremia in patients with sepsis syndrome in the intensive care unit.
Because lipid A is essentially the same among most species of gram-negative bacteria, drug companies initially sought ways to inactivate it as a possible means of treating sepsis syndrome.
Limulus amebocyte lysate assay for detection of endotoxin in patients with sepsis syndrome.
Sepsis syndrome is the 11th leading cause of death in the United States and the incidence has been increasing over the past 20 years.
639), but neurologic and sepsis syndromes had markedly lower agreement than other syndromes (kappa statistics 0.
Seventeen days after transplant, sepsis syndrome and renal failure developed while the patient was still profoundly granulocytopenic ([is less than] 0.
and the IL-1ra Phase III Sepsis Syndrome Study Group; From the Department of Pulmonary and Critical Care Medicine, The Cleveland Clinic Foundation and Case Western Reserve University, Cleveland, OH (CJF); Service De Reanimation Medicale, Cochin Port Royal University, Paris, France (JFD); Synergen, Inc.
Tumor Necrosis Factor, or TNF, is believed to play a central role in the development of the sepsis syndrome and shock.
Selectide is contributing its proprietary drug discovery technology to the collaboration, while Synergen brings its preclinical and clinical experience with cytokine inhibitors including TNF binding proteins and ANTRIL(TM), the company's IL-1 receptor antagonist (IL-1ra), now in clinical trials for a number of indications including sepsis syndrome.
With revenue from Receptech, two potential therapeutic candidates have advanced into human clinical trials: Interleukin-1 receptor, which is being tested in allergy, rheumatoid arthritis, graft versus host disease and a model of sepsis syndrome, and TNF receptor, which is currently under clinical study for the treatment of sepsis.
The state-of-the-art manufacturing facility will annually produce approximately 1,500 kilograms (3,200 pounds) of a drug called anakinra, which is the active ingredient in ANTRIL(TM) -- a product being investigated for use in sepsis syndrome.