Senile plaque

senile plaque

n.

A spherical mass of amyloid fibrils surrounded by distorted interwoven neuronal processes, found in the cerebral cortex in Alzheimer's disease. Also called neuritic plaque.

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Senile plaque

—Structures composed of parts of neurons surrounding brain proteins called beta-amyloid deposits found in the brains of people with AD.

Mentioned in: Alzheimer's Disease

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plaque

1. any patch or flat area.

2. a clear area of cell lysis caused by viral replication on a cell monolayer.

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amniotic plaque

small, 1 to 2 inch diameter, poxlike lesion on the inside of the amnion. Constant on the bovine amnion during the middle trimester and causes no problems.

annular plaque

seen in equine lupus erythematosus panniculitis.

plaque assay

a method of quantifying the number of infectious units by inoculating serial dilutions of a viral suspension on a cell culture monolayer, overlaying with a medium containing agarose and after several days incubation, counting the number of plaques formed; recorded as plaque forming units/ml.

atheromatous plaque

a deposit of predominantly fatty material in the lining of blood vessels occurring in atherosclerosis.

bacterial plaque, dental plaque

a mass adhering to the enamel surface of a tooth, composed of a mixed colony of bacteria in an intercellular matrix of bacterial and salivary polymers and remnants of epithelial cells and leukocytes. It may cause caries, dental calculi and periodontal disease.

cutaneous plaque

an elevated, solid structure without a necrotic center, up to 1 to 2 inch diameter with an unbroken surface.

drug plaque

cutaneous, subcutaneous or subconjunctival deposits formed as a result of injection of some drugs, particularly repository steroid preparations. May be unsightly and a cause of conjunctivitis.

ear plaque

see ear plaque.

eosinophilic plaque

see eosinophilic plaque.

plaque-forming cells

see plaque assay (above).

plaque-forming count

the number of plaques formed in the plaque assay.

senile plaque

described in the brain of old dogs.

siderotic plaque

nodules observed as dry, yellow encrustations on the splenic capsule of old dogs.