senile plaque


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se·nile plaque

an obsolete term for neuritic plaque.

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.

se·nile plaque

(sen'il plak)
A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.

Senile plaque

—Structures composed of parts of neurons surrounding brain proteins called beta-amyloid deposits found in the brains of people with AD.
Mentioned in: Alzheimer's Disease

plaque

1. any patch or flat area.
2. a clear area of cell lysis caused by viral replication on a cell monolayer.

amniotic plaque
small, 1 to 2 inch diameter, poxlike lesion on the inside of the amnion. Constant on the bovine amnion during the middle trimester and causes no problems.
annular plaque
seen in equine lupus erythematosus panniculitis.
plaque assay
a method of quantifying the number of infectious units by inoculating serial dilutions of a viral suspension on a cell culture monolayer, overlaying with a medium containing agarose and after several days incubation, counting the number of plaques formed; recorded as plaque forming units/ml.
atheromatous plaque
a deposit of predominantly fatty material in the lining of blood vessels occurring in atherosclerosis.
bacterial plaque, dental plaque
a mass adhering to the enamel surface of a tooth, composed of a mixed colony of bacteria in an intercellular matrix of bacterial and salivary polymers and remnants of epithelial cells and leukocytes. It may cause caries, dental calculi and periodontal disease.
cutaneous plaque
an elevated, solid structure without a necrotic center, up to 1 to 2 inch diameter with an unbroken surface.
drug plaque
cutaneous, subcutaneous or subconjunctival deposits formed as a result of injection of some drugs, particularly repository steroid preparations. May be unsightly and a cause of conjunctivitis.
ear plaque
see ear plaque.
eosinophilic plaque
see eosinophilic plaque.
plaque-forming cells
see plaque assay (above).
plaque-forming count
the number of plaques formed in the plaque assay.
senile plaque
described in the brain of old dogs.
siderotic plaque
nodules observed as dry, yellow encrustations on the splenic capsule of old dogs.
References in periodicals archive ?
Since many of the above-described findings can occur in non-demented elderly patients, an accurate pathologic diagnosis of AD requires information regarding the age and clinical history of the patient as well as an evaluation of the number and distribution of senile plaques and neurofibrillary tangles.
Studies in mice have shown that memory loss correlates more strongly with the presence of ADDLs than with the presence of senile plaques, and that treatments to reduce ADDL levels can actually reverse memory loss.
The PET image shows high densities of [beta]-amyloid senile plaques and neurofibrillary tangles in the hippocampal region.
The appearance of microglia in senile plaques is a late event in DS, and it coincides with the development of neuritic changes in A[Beta] plaques and of NFTs.
The computer, which fills the space of two basketball courts, will be put to many uses, one of which is to analyze the formation of senile plaques in the brains of patients with Alzheimer's disease.
In 1984, researchers discovered that these senile plaques consist of a central core of beta amyloid protein, surrounded by a cluster of abnormal nerve cells clogged with twisted fibers called neurofibrillary tangles.
Accumulations of beta-amyloid are believed to form senile plaques and cause brain cell death.
It may also inhibit senile plaques from depositing in the brain, which impairs cognition.
Microglial cells, the nervous system's defenders, are unable to eliminate this substance, which forms deposits called senile plaques.
The neuropathological hallmarks of Alzheimer's disease (AD) are senile plaques, cerebrovascular beta-amyloidosis, neurofibrillary tangles, and selective neuronal loss.
2]M is associated with senile plaques (3), binds to A[beta] peptide, the major component of [beta]-amyloid (4); attenuates fibrillogenesis and neurotoxicity of A[beta] (4,5); and mediates A[beta] degradation (6,7).
Many people who are mildly forgetful may go on to develop the disease because these senile plaques start forming years before any symptoms manifest themselves.