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self-antigen

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self-antigen /self-an·ti·gen/ (self-an´tĭ-jen) autoantigen.
self-antigen.
self-antigen [self-an´tĭ-jen]
any constituent of the body's own tissues capable of stimulating autoimmunity. See also immunity.

self-antigen
any constituent of the body's own tissues capable of stimulating autoimmunity. See also immunity.


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Thus, basic questions such as those related to possible consequences, for immune responses in infectious diseases and cancer, of age-related alterations of antigen processing and presenting, change with age of self-antigen repertoire, and the genetic basis of immunoproteasome activity and its change with age, remain largely unanswered.
In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (collagen, myelin basic protein, and cardiac myosin, respectively).
Cellular and humoral immune reaction against a variety of neural cell antigens, such as myelin basic protein, myelin oligodendrocyte glycoprotein, myelin associated glycoprotein, ganglioside, sulfatide, and many other self-antigens, may result in a neuroimmune disorder including interference with neurotransmission.
 
 
 
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