selenium deficiency

selenium deficiency

Cardiology An absence of selenium in the diet, with ↑ binding of hepatic nucleoproteins to DNA regulatory sequences, and activation of transcription in response to oxidative stress; SD has been implicated in colon polyp formation, endemic cardomyopathy, Keshan disease–attributed to a defect in glutathione peroxidase activity, without which there is ↑ platelet aggregation due to impaired free radical salvage or in the catalytic function of type I deiodinizing thyroxine-activating enzyme. See Keshan disease.
References in periodicals archive ?
Selenium deficiency and thyroid autoimmunity did not contribute to the high prevalence of goitre, however, coexistent iron deficiency state correlated with the presence of goitre.
Thioredoxin reductase activity is decreased by selenium deficiency.
For example, elevated concentrations of chromium has been found in the hair of people suffering from diabetes mellitus while Kashin-Beck disease has been attributed to a selenium deficiency.
The largest problem seems to be with selenium deficiency which has been affecting fertility.
The researchers point out that this raises a potentially important public health question: has selenium deficiency been overlooked as a cause of anemia among older adults?
Selenium deficiency is associated with Keshan disease, a fatal form of cardiomyopathy.
Selenium deficiency has been reported to exacerbate the effects of coexisting iodine deficiency through which of the following:
For example, a cardiomyopathy in China, the so-called Keshan disease, is due to selenium deficiency in the diet (1, 2).
Watkinson JH (1983) Prevention of selenium deficiency in grazing animals by annual top-dressing of pasture with sodium selenate.
The anticarcinogenic properties of selenium at high doses suggest a possible link between selenium deficiency and cancer (3).
Meanwhile, selenium deficiency could increase the risks of prostate colon cancers; cardiovascular disease as well as other health problems.
Selenium deficiency, although rare, is associated with Keshan disease, which is a type of cardiomyopathy affecting mainly children and young women primarily in China where selenium intake is low.