selenium deficiency

selenium deficiency

Cardiology An absence of selenium in the diet, with ↑ binding of hepatic nucleoproteins to DNA regulatory sequences, and activation of transcription in response to oxidative stress; SD has been implicated in colon polyp formation, endemic cardomyopathy, Keshan disease–attributed to a defect in glutathione peroxidase activity, without which there is ↑ platelet aggregation due to impaired free radical salvage or in the catalytic function of type I deiodinizing thyroxine-activating enzyme. See Keshan disease.
References in periodicals archive ?
7,8) According to previous studies, zinc and selenium deficiency is common in cirrhosis and can affect nitrogen metabolism.
It is also reported that selenium deficiency decreases resistance of the animal against various diseases (Huang and Yang, 2002).
Selenium deficiency has been associated with cognitive decline in the elderly (Akbaraly et al.
The risk of selenium deficiency is lower for horses fed on industrial feeds, as these are supplemented with mineral additives.
Effect of dietary selenium deficiency on the in vitro fertilizing ability of mice spermatozoa.
Selenium deficiency can cause a series of symptoms, such as cardiovascular disease, Kaschin-Beck disease and Keshan disease.
However, studies that have evaluated the prevalence of selenium deficiency among HIV-infected children are limited.
However, the finding from the present study, that selenium supplementation increased glutathione peroxidase activity in patients with cirrhosis, appears to indicate that these patients had a mild functional selenium deficiency.
Some years ago I tried a vegetarian diet and suffered with zinc and selenium deficiency.
Clinical syndromes of selenium deficiency include white muscle disease (nutritional muscular dystrophy) in ruminants (Ammerman and Miller 1975; Swecker, 1997), along with reduced appetite, growth, production and reproductive fertility, retained placenta, general unthriftiness and muscular weakness, increased susceptibility to mastitis (Blood and Radostits, 1989).
One of the main reasons why selenium deficiency is so damaging to heart muscle is because of the role selenium plays in protecting the heart against free radical damage, a leading risk factor for heart disease.