selective serotonin reuptake inhibitor


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inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

selective serotonin reuptake inhibitor

a class of chemical compounds that selectively, to varying degrees, inhibit the reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.

selective serotonin reuptake inhibitor

n.
An SSRI.

selective serotonin reuptake inhibitor (SSRI)

an antidepressant drug that blocks reuptake of serotonin without blocking reuptake of other biogenic amines such as norepinephrine and dopamine. Advantages over tricyclic antidepressant drugs include fewer anticholinergic side effects (dry mouth, blurred vision, urinary retention) and fewer antihistaminic side effects (sedation, weight gain).

selective serotonin reuptake inhibitor

Serotonin-selective-reuptake inhibitor, see there.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-ŭp'tāk in-hib'i-tŏr)
A class of drugs that selectively prevent the reuptake of serotonin and are used for the treatment of depression, e.g., fluoxetine, sertraline.

Selective serotonin reuptake inhibitor (SSRI)

A class of antidepressants that work by blocking the reabsorption of serotonin in the brain, raising the levels of serotonin. SSRIs include Prozac, Zoloft, and Paxil.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-up'tāk in-hib'i-tŏr)
Class of chemical compounds that selectively, to varying degrees, inhibit reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.
References in periodicals archive ?
First-trimester use of selective serotonin reuptake inhibitors and the risk of birth defects.
Selective serotonin reuptake inhibitors (SSRIs) are considered less toxic and have rarely been implicated in the induction of rhabdomyolysis.
Key Topics Covered: Executive Summary Strategic Considerations Stakeholder Implications Introduction Overview of Panic Disorder Disease Description Diagnosis Pathophysiology of Panic Disorder Norepinephrine Serotonin Gamma-Aminobutyric Acid Glutamate Corticotropin-Releasing Factor Substance P Prevalence of Panic Disorder Current Therapies for Panic Disorder Selective Serotonin Reuptake Inhibitors Serotonin and Norepinephrine Reuptake Inhibitors Benzodiazepines Emerging Therapies for Panic Disorder Sepracor's SEP-225441 Alexza Pharmaceuticals' AZ-002 Panic Disorder Market: 2007 Statistics and Future Outlook
An analysis of data from a large, federally funded clinical trial indicates that when such patients take antidepressant medication of the class known as selective serotonin reuptake inhibitors (SSRIs), they reap major heart-health benefits.
Selective serotonin reuptake inhibitors (SSRIs), such as Prozac and fluvoxamine, currently are used to treat people with depression and obsessive-compulsive disorder, a condition in which a person cannot control impulses to constantly wash his hands, count things or engage in other repetitive behavior.
A product of Solvay Pharmaceuticals' innovative research in psychiatry, fluvoxamine was introduced in 1983 in Europe as one of the very first selective serotonin reuptake inhibitors (SSRI).
Studies have shown that calcium supplements, as well as antidepressant medications known as selective serotonin reuptake inhibitors (SN: 10/7/00, p.
Researchers now report that popular antidepressants called selective serotonin reuptake inhibitors (SSRIs) might diminish the effectiveness of tamoxifen by limiting its conversion into medicinally important agents.
As with tricyclic antidepressants and selective serotonin reuptake inhibitors, EFFEXOR is a weak inhibitor of the reuptake of dopamine, another neurotransmitter associated with depression.
Patients with depression who take tricyclic antidepressants and selective serotonin reuptake inhibitors concurrently have almost twice the risk of developing type 2 diabetes as those taking tricyclic medications alone, Lauren C.
In a new study, researchers provide evidence that, in young mice, the antidepressants known as selective serotonin reuptake inhibitors (SSRIs) permanently alter the brain, resulting in a greater risk of depression and anxiety in adulthood.
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