Selective progesterone receptor modulators
and progesterone antagonists: mechanisms of action and clinical applications.
As a selective progesterone receptor modulator
, asoprisnil has an agonist/antagonist effect on progesterone receptors, with high tissue selectivity.
HOUSTON -- The investigational selective progesterone receptor modulator
asoprisnil induced amenorrhea or normal menstrual periods in a clear majority of women with myoma-associated menorrhagia in a multicenter phase II study.
A selective progesterone receptor modulator
(SPRM), asoprisnil is thought to work by inhibiting blood flow at the endometrial level, thus significantly reducing bleeding associated with leiomyomas.
3] FIBRISTAL (TM) is the first in a new class of medications in Canada called selective progesterone receptor modulators
ellaOne(R) is the first representative of a new therapeutic class, selective progesterone receptor modulators
, and is the first molecule to have been specifically designed and developed for use as an oral emergency contraceptive.