competitive inhibition

(redirected from selective inhibition)
Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to selective inhibition: COX-2 selective inhibitor

inhibition

 [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

com·pet·i·tive in·hi·bi·tion

blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate. The competitive inhibitor is often a substrate analogue and binds at the active site; however, this is not an absolute requirement for competitive inhibition. Saturating concentrations of substrate can remove the inhibition. Compare: isostery.

com·pet·i·tive in·hi·bi·tion

(kŏm-pet'i-tiv in'hi-bish'ŭn)
Blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate.
Synonym(s): selective inhibition.

competitive inhibition

a form of enzyme control in which an inhibitor molecule very similar in structure to the normal SUBSTRATE of an enzyme becomes reversibly bound to the ACTIVE SITE, thus reducing the quantity of enzyme available. However, if excess substrate is present the inhibitor can be forced out by the substrate molecule which takes its place and the reaction proceeds. Compare NONCOMPETITIVE INHIBITION.

inhibition

arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.
References in periodicals archive ?
Preliminary results from the first clinical evaluation of ACY-1215 suggest that selective inhibition of HDAC6 with ACY-1215 is well tolerated as monotherapy at exposures that demonstrate increased acetylation of tubulin, a biomarker of HDAC6 inhibition, versus acetylation of histones, a Class I HDAC inhibitory effect.
But unlike these drugs, ladostigil, which also causes brain selective inhibition of monoamine oxidase (MAO) provides the potential to improve the behavioral and psychological symptoms of dementia such as depression and anxiety.
McDonald at the University of California, San Francisco (UCSF), showed that selective inhibition of VEGF signaling with a neutralizing antibody against VEGF or with a small molecule kinase inhibitor resulted in more invasive and metastatic tumors than from placebo-treated mice.
The assets of the company include ongoing Phase 1 clinical programs involving selective inhibition of mTOR kinase and isoform-specific inhibition of PI3K, as well as a partnered program involving research and development of isoform-specific inhibitors of PI3K/, and a robust discovery research platform in small molecule kinase inhibitors.
Data presented in the publication confirm the selective inhibition of USP7 in human cells treated with P022077, in contrast to the pan-DUB inhibition profile of the tool compound PR-619 in the same cells.
We are already exploring the treatment of hematological cancers in a Phase 1b clinical study of AVL-292, and believe that the selective inhibition of Btk has applications for a wide range of B cell mediated diseases.
This presentation will focus on the CAT1000 series of new chemical entities and the underlying inflammatory response in type 2 diabetes that is rebalanced and resolved by selective inhibition of pro-inflammatory pathways and activation of endogenous anti-inflammatory pathways.
Selective inhibition of the intracellular enzyme HDAC6 may provide enhanced anti-cancer effectiveness through potentially reduced side effects and improved tolerability compared to current non-selective inhibitors, which are active against both Class I and Class II HDACs.
The data reinforce the potential of AVL-292 to treat B cell malignancies such as chronic lymphocytic leukemia (CLL) through potent and selective inhibition of Btk.
Selective inhibition of SGLT2 by an insulin independent mechanism of action is designed to lead to the excretion of excess glucose and associated calories in the urine, thereby lowering blood glucose levels.

Full browser ?