selective IgA deficiency

selective IgA deficiency

a familial or acquired disorder characterized by a lack of serum and secretory immunoglobin A (IgA). The IgA-deficient patient may appear normal or asymptomatic and is diagnosed by demonstration of less than 5 mg/dL of IgA in serum. Patients have an increased risk of respiratory, GI, and urogenital infections.
References in periodicals archive ?
Anti-tissue transglutaminase IgA assays which produce results with no detectable IgA antibody may be indicative of a patient with selective IgA deficiency, and these patients should be further investigated.
Kalha and Sellin, however, argue that CVID is the second most common PID, second to selective IgA deficiency (4).
Selective IgA deficiency in children with recurrent parotitis of childhood.
De Laat PCJ, Weermaes CMR, Gonnera R et al Clinical manifestations in selective IgA deficiency in chilhood.
For example, selective IgA deficiency is present in 1 in 400-700 individuals, most of whom have no idea they have an immunodeficiency disorder.
Initial tests pointed to asthma, but Debbie pushed for a second opinion and a year later James, now a pupil at Milecastle Primary School, was diagnosed with selective iga deficiency.
Contraindications: Prolastin must not be used in patients with selective IgA deficiency who are known to have antibodies against IgA, as allergic reactions to the point of anaphylactic shock may occur in such cases and in patients known to be hypersensitive to alpha1-proteinase inhibitors or any of the excipients.
Selective IgA deficiency occurs in 1 of 39 to 57 patients with celiac disease (1-3).

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