19,20) There are several types of selectins
in the body, and they facilitate physical interaction and locomotion of various cell types.
3) The most important initiators of adhesion are the three selectins
expressed on leukocytes (L-selectin
), endothelial cells (E-selectin
), and activated platelets (P-selectin
About SelG1 SelG1 is an investigational humanized monoclonal antibody directed against P-selectin
, a key member of the adhesion molecule family known as the selectins
In experiments with diluted whole blood spiked with a known concentration of hematopoietic cancer cells, the mixture of selectins
and antibodies yielded significantly higher recoveries of CTCs than with antibodies alone.
Some studies suggest that selectins
arc expressed in diseases of the gingival epithelia.
belongs to a family of structurally related selectin
E, P and L participate in endothelial leukocyte adhesion (1).
The technique involves filling the tiny lipid containers, or nanoscale capsules, with a molecular cargo and coating the capsules with adhesive proteins called selectins
that specifically bind to target cells.
The sLex carbohydrate on TP20 binds to adhesion molecules called selectins
that are expressed on endothelial cells and platelets and blocks those cells from interacting with other inflammatory cells, including neutrophils.
A third type, the selectins
, pierces the outer cell membrane in the form of a single zigzag.
are the main receptors that mediate the initial capture of circulating leukocytes to vascular endothelial surfaces (McEver 2002).
The device consists of a 300-[micro]m (inner diameter) microtube coated with selectins
This carbohydrate binds to selectins
, adhesion molecules expressed on endothelial cells and platelets during inflammation, thus allowing TP20 to target sites of vascular inflammation.