1992) An endothelial ligand for L selectin
is a novel mucin-like molecule.
The importance of fucoidan's interaction with selectins
goes well beyond cancer defense.
are constitutively active, integrins must be activated to mediate adhesion.
Some of the well-recognized platelet receptors are; integrins, leucine-rich repeats receptors, selectins
, tetraspanins, transmembrane receptors, prostaglandin receptors, lipid receptors, immunoglobulin superfamily receptors, tyrosine kinase receptors and miscellaneous platelet receptors.
Clinical and biochemical values in CAD patients with selectin
genotypes Characteristics Genotype S/S (n=273) S/R (n=56) Age 57.
were measured using ELISA-based assays (R&D Systems).
The sLex carbohydrate on TP20 binds to adhesion molecules called selectins
that are expressed on endothelial cells and platelets and blocks those cells from interacting with other inflammatory cells, including neutrophils.
A third type, the selectins
, pierces the outer cell membrane in the form of a single zigzag.
are the main receptors that mediate the initial capture of circulating leukocytes to vascular endothelial surfaces (McEver 2002).
In experiments with diluted whole blood spiked with a known concentration of hematopoietic cancer cells, the mixture of selectins
and antibodies yielded significantly higher recoveries of CTCs than with antibodies alone.
and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow.
This carbohydrate binds to selectins
, adhesion molecules expressed on endothelial cells and platelets during inflammation, thus allowing TP20 to target sites of vascular inflammation.