selectins


Also found in: Encyclopedia.

selectins

a large family of membrane proteins that bind oligosaccharides on other cells tightly and specifically, and are involved in signal transduction across the plasma membrane.
References in periodicals archive ?
1992) An endothelial ligand for L selectin is a novel mucin-like molecule.
The importance of fucoidan's interaction with selectins goes well beyond cancer defense.
Whereas selectins are constitutively active, integrins must be activated to mediate adhesion.
Some of the well-recognized platelet receptors are; integrins, leucine-rich repeats receptors, selectins, tetraspanins, transmembrane receptors, prostaglandin receptors, lipid receptors, immunoglobulin superfamily receptors, tyrosine kinase receptors and miscellaneous platelet receptors.
Clinical and biochemical values in CAD patients with selectin genotypes Characteristics Genotype S/S (n=273) S/R (n=56) Age 57.
The selectins were measured using ELISA-based assays (R&D Systems).
The sLex carbohydrate on TP20 binds to adhesion molecules called selectins that are expressed on endothelial cells and platelets and blocks those cells from interacting with other inflammatory cells, including neutrophils.
A third type, the selectins, pierces the outer cell membrane in the form of a single zigzag.
Selectins are the main receptors that mediate the initial capture of circulating leukocytes to vascular endothelial surfaces (McEver 2002).
In experiments with diluted whole blood spiked with a known concentration of hematopoietic cancer cells, the mixture of selectins and antibodies yielded significantly higher recoveries of CTCs than with antibodies alone.
This carbohydrate binds to selectins, adhesion molecules expressed on endothelial cells and platelets during inflammation, thus allowing TP20 to target sites of vascular inflammation.