selamectin


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selamectin

(sel-ă-mek'tin),
An antiparasiticide member of the avermectin group, this semisynthetic veterinary drug is a modified version of doramectin; a macrocyclic lactone, this isolate results in the lowest toxicity in Collies; usually applied topically on a monthly basis, indications are for prevention of Dirofilaria immitis, Ctenocephalides felis, Sarcoptes scabeii, Dermacentro variabilis, Otodectes cynotis, and in cats, also Ancylostoma tubaeforme and Toxocara cati; commercial solution is flammable. Acts by enhancing gamma amino butyric acid release at the presynaptic membrane and enhancing chloride permeabilty, resulting in parasite paralysis and death. Not effective against flukes or tapeworms.

selamectin

a macrocyclic lactone parasiticide, one of the avermectins effective against internal and external parasites with sustained absorption when used topically in dogs and cats.
References in periodicals archive ?
At this age, this bird had been dosed three times with a fipronil/methoprene combination (2 and 1mg) and three times with pour on selamectin (2mg).
According to the company, the active substances in Stronghold Plus are selamectin and sarolaner, a new combination of parasiticides.
Selamectin, Ivermectin and Fipronil are effective treatment of ear mite topically or systemically after mechanical cleaning of ear canal (Blot et al.
Other drugs including Selamectin have shown to reduce the number of cat fleas [21].
Both cats were treated with spot-on solution containing 6% selamectin (Stronghold(R), Pfizer, Belgium) according to previous studies (Leone and Albanese, 2004; MartiOlle et al.
Two additional doses of ivermectin and 2 doses of topical selamectin (23 mg/kg) were administered 2 and 4 weeks apart, respectively.
Improved canine chemoprophylaxis may require combinations or sequential dosages of the macrocyclic lactones including ivermectin, moxidectin, selamectin, and milbemycin oxime; or by adding another effective antifilarial medication, such as melarsomine dihydrochloride to the prophylactic regimen.
REVOLUTION * Fleas * SELAMECTIN (two Do not administer
Topical selamectin (Stronghold, Pfizer, USA) at a single dose of 6 mg/kg was administered on the area between shoulders of the dogs that were diagnosed with toxocariosis.
Chailleux N, Paradis M: Efficacy of selamectin in the treatment of naturally acquired cheyletiellosis in cats.
Chemicals that have historically been used to control ticks include organophosphates, carbamates, pyrethrins, synthetic pyrethroids, formamidines, fipronil, and selamectin.
Selamectin--A new topical liquid treatment sold as Revolution, selamectin is labeled for control of fleas, ticks, heartworm, roundworm and hookworm in cats.