They show that BIS-001 is a powerful inhibitor of acetylcholinesterase, which in turn increases GABA levels that activate anti-excitatory pathways and result in improved seizure control
Treatment of partial-onset seizures, the most common type of epilepsy, presents a constant challenge - up to 40% of patients with partial-onset seizures do not achieve sustained seizure control
with current anti-epileptic drugs (3).
The setting on the patient's VNS device will be gradually increased over a number of weeks in an effort to improve his seizure control
In fact, levetiracetam provided seizure control
comparable with that of older antiepileptic drugs (AEDs) carbamazepine and valproate but superior when compared with other newer AEDs, including lamotrigine and topiramate.
Professor Rajat Gupta, Consultant Paediatric Neurologist at the Hospital, said: "This was part of our on-going work to not only improve their seizure control
, but also allow them and their families to build friendships and share their experiences.
This also presents a set of risks and challenges inasmuch as it has been documented that use of more than three AED's adds very little benefit to the overall seizure control
It s important to get seizure control
at any age, but in children, uncontrolled seizures may impact brain and neurocognitive development, which can have an extraordinary effect on quality of life and contribute to progressive cognitive impairment.
Some patients with epilepsy do not achieve satisfactory seizure control
from existing treatments,'' Dr.
While a significant minority of children with early medical intractability ultimately achieved seizure control
without surgery, those with an abnormal imaging study did poorly," said Dr.
She did very well with the combination of medications and enjoyed some improvement in her seizure control
Adequate seizure control
of this most common form of epilepsy remains an unmet medical need for a significant number of patients and Sunovion is committed to providing a treatment option to help address this need.
The reference includes a foreword by the director of The Charlie Foundation to Help Cure Pediatric Epilepsy, answers to frequently asked questions, tips for regaining lost seizure control
, research findings, sample meal plans, and resources.