secretory diarrhea


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Related to secretory diarrhea: cholera, osmotic diarrhea

secretory diarrhea

voluminous water diarrhea as occurs in association with cholera, in which the toxin stimulates intestinal secretion.

secretory diarrhea

Diarrhea in which there is a large volume of fecal output caused by abnormalities of the movement of fluid and electrolytes into the intestinal lumen. This can be caused by hormonal abnormalities present in disorders such as carcinoid syndrome, Zollinger-Ellison syndrome, certain types of pancreatic adenomas, and medullary carcinomas of the thyroid.
See also: diarrhea

diarrhea

rapid movement of fecal matter through the intestine resulting in poor absorption of water, nutritive elements and electrolytes, and producing abnormally frequent evacuation of watery droppings. The major causes are local irritation of the intestinal mucosa by infectious or chemical agents (gastroenteritis). In all types of diarrhea there is rapid evacuation of water and electrolytes resulting in a loss of these essential substances. Base (bicarbonate) especially is depleted by diarrhea, thus producing acidosis as well as fluid volume deficit.

acute idiopathic diarrhea
acute diarrhea syndromes in horses which are not diagnosable, such as salmonellosis, strongylosis, cyathostomiasis, Potomac horse fever, colitis-X, antibiotic-induced diarrhea (above), intestinal clostridiosis.
acute undifferentiated diarrhea of the horse
severe, acute diarrhea likely to be fatal may be related to stress or antibiotic therapy. See also colitis-X, intestinal clostridiosis, salmonellosis.
antibiotic-associated diarrhea
results from disruption of the normal bowel flora as a result of antimicrobial therapy for any reason. May occur as moderate diarrhea or as a life threatening syndrome often with severe colitis or pseudo-membranous colitis. See also antibiotic-associated colitis.
bovine virus diarrhea
see bovine virus diarrhea.
campylobacter diarrhea
watery diarrhea without other obvious signs and without other obvious cause in yearling sheep, calves and foals. Campylobacter fetus subspp. jejuni and intestinalis have been suggested as causes. See also winter dysentery.
chronic undifferentiated diarrhea of the horse
chronic, very watery diarrhea for very long periods but the horse has normal appetite and loses weight only gradually. Esthetically very displeasing to pleasure horse owners. Irreversible but not usually fatal.
ciliate diarrhea
colitis caused by troglodytella in primates.
dietary diarrhea
a result of dietary indiscretion; occurs in all species. It is caused by the chemical or physical nature of the ingested material. The commonest occurrence of the syndrome is in newborn animals, especially those who ingest too much milk. There is often a history of access to an oversupply of milk or of a recent change of source to an over-rich milk replacer or indigestible components in replacer. It is also caused by too-rapid drinking. Affected animals are bright and alert and have a normal appetite but the feces are voluminous, soft to fluid and evil-smelling. Secondary bacterial enteritis may ensue but most cases recover spontaneously when the diet is adjusted. Scavenging dogs and cats ('garbage eaters') commonly ingest food that is spoiled or to which they are unaccustomed, resulting in various degrees of vomiting or diarrhea. Called also dietetic scours.
effusion diarrhea
caused by an increase in the transepithelial hydrostatic pressure gradient, such as occurs in congestive heart failure and hepatic portal hypertension.
epizootic porcine diarrhea
at least two types of epidemic diarrhea occur in pigs which are not transmissible gastroenteritis or due to other known cause.
large bowel diarrhea
in dogs and cats, signs referable to the site of enteric disease responsible for the diarrhea being the large intestine include tenesmus, mucus, hematochezia, and increased frequency of defecation.
malabsorptive diarrhea
villous atrophy, such as occurs with some viral infections, causes malabsorption diarrhea because of the reduction in area of absorptive intestinal epithelium.
nursery diarrhea
see nursery diarrhea.
osmotic diarrhea
an overload of unabsorbed osmotically active particles will attract and retain water, increasing fecal volume and causing diarrhea. Associated with maldigestion, malabsorption, overeating, excessive carbohydrates or fats. The basis for the laxative effect of magnesium sulfate, sodium sulfate or sodium phosphate.
psychogenic diarrhea
see irritable colon syndrome.
secretory diarrhea
derangement of normal secretory and absorptive functions of intestinal epithelium such as occurs with bacterial enterotoxins may result in excessive secretion and a resulting diarrhea. Escherichia coli is the prime example of an infection with this effect.
small bowel diarrhea
in dogs and cats, signs referable to the site of enteric disease responsible for the diarrhea being the small intestine include lack of tenesmus or mucus, increased fecal volume, melena and weight loss.
undifferentiated diarrhea of the newborn
the situation in which a newborn animal (less than 7 days old) has life-threatening acute diarrhea. There is insufficient time and it would cost too much to differentiate between all of the possible causes. Added to this is the common occurrence in which there are two or more agents present, often acting in concert. Because of the need to treat these cases urgently and effectively if their lives are to be saved it has become the practice to group them together for the purposes of treatment and prognosis.

secretory

pertaining to secretion.

secretory cells
the specialized cells in a secretory gland that perform the secretory function.
secretory component
a polypeptide synthesized by epithelial cells that binds to IgA to form secretory IgA (SIgA).
secretory diarrhea
see secretory diarrhea.
secretory endpieces
secretory granules
intracellular granules composed of secretory proteins after their conversion by the Golgi apparatus.
secretory IgA (SIgA)
a class of immunoglobulin found in some body secretions, e.g. saliva, respiratory secretions, milk and colostrum, that is responsible for local immunity. See also immunoglobulin.
References in periodicals archive ?
Napo has exclusive rights to several classes of novel, proprietary, small-molecule CFTR inhibitors, which it is developing for a variety of indications, including PKD and secretory diarrheas, which may include diarrheas of infectious or other origins.
Secretory diarrhea is the second leading cause of death in early childhood in developing countries.
Conversely, inhibitors are potentially useful to treat secretory diarrhea caused by enterotoxins, as the CFTR is the main route for Cl- flux in the intestine and polycystic kidney disease.
The secretory diarrhea technology is based on inhibition of an ABC transporter called CFTR.
Verkman recently discovered a series of compounds that inhibit CFTR and are candidates for the treatment of secretory diarrhea.
In tropical regions with flood disasters, like in Mozambique today, a significant percentage of people who contract intestinal infections, have secretory diarrhea.
The paper concludes that oral clotrimazole and drugs of related structure may have utility in the treatment of acute and chronic secretory diarrheas from diverse origins.
The principal route for apical chloride secretion in cholera and other enterotoxin-mediated secretory diarrheas in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel.