secretin


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Related to secretin: cholecystokinin, CCK, secretin test

se·cre·tin

(se-krē'tin), [MIM*182099]
A hormone, formed by the epithelial cells of the duodenum under the stimulus of acid contents from the stomach, which incites secretion of pancreatic juice; used as a diagnostic aid in the diagnosis of pancreatic exocrine disease and as an adjunct in obtaining desquamated pancreatic cells for cytologic examination.
Synonym(s): oxykrinin
[secrete + -in]

secretin

/se·cre·tin/ (se-kre´tin) a hormone secreted by the duodenal and jejunal mucosa when acid chyme enters the intestine; it stimulates secretion of pancreatic juice and, to a lesser extent, bile and intestinal secretion.

secretin

(sĭ-krēt′n)
n.
A polypeptide hormone that is produced in the duodenum, especially on contact with acid, and that inhibits gastric secretion of acid and stimulates secretion of bile, insulin, and pancreatic digestive enzymes.

secretin

[sikrē′tin]
Etymology: L, secernere, to separate
a digestive hormone that is produced by the S cells lining the duodenum and jejunum when protein of partially digested food enters the intestine from the stomach. It stimulates the pancreas to produce a fluid high in salts but low in enzymes. Secretin has a limited stimulating effect on the production of bile. See also pancreas.

se·cre·tin

(sĕ-krē'tin)
A hormone, formed by the epithelial cells of the duodenum under the stimulus of acid contents from the stomach, that incites secretion of pancreatic juice; used as an aid in the diagnosis of pancreatic exocrine disease and as an adjunct in obtaining desquamated pancreatic cells for cytologic examination.
Compare: bioregulator

secretin

A hormone secreted in the DUODENUM that prompts the production of PANCREATIC JUICE.

secretin

a hormone responsible for the secretion of bile from the liver.

se·cre·tin

(sĕ-krē'tin) [MIM*182099]
Hormone formed by epithelial cells of duodenum under stimulus of acid contents from stomach, which incites secretion of pancreatic juice.

secretin

a hormone secreted by the mucosa of the duodenum and jejunum when acid chyme enters the intestine; carried by the blood, it stimulates the secretion of pancreatic juice and, to a lesser extent, bile and intestinal secretion.

secretin test
an examination of the gastric and duodenal contents after intravenous administration of exogenous secretin; useful in the diagnosis of disorders affecting pancreatic exocrine function, for example, pancreatitis and neoplastic disease.
References in periodicals archive ?
Synthetic secretin is packaged in a powdered form and refrigerated, then reconstituted in saline just prior to injection.
Generally, CCK induces a decrease in the viscosity of intestinal content, activates bicarbonate secretion into the intestine, and increases the efficiency of secretin (Meyer et al.
Repligen is currently conducting a multi-center Phase 2/3 clinical trial of RG1068 as an agent to improve the detection of structural abnormalities of the pancreatic ducts during MRI imaging of the pancreas as well as a Phase 1 investigator study to assess the utility of secretin for functional imaging of the pancreas.
A protein that occurs naturally in the gut, secretin gained notice as a potential autism cure in 1998, when news media reported a ease in which the substance seemingly cured an autistic boy.
rProtein A(TM) is a consumable reagent used by the pharmaceutical industry to produce a class of drugs called monoclonal antibodies and SecreFlo(TM), secretin for injection, is marketed to gastroenterologists for pancreatic assessment and for use during a gastrointestinal procedure called ERCP.
A randomized, double-blind, placebo-controlled trial of single-dose intravenous secretin as treatment for children with autism.
A recent study that found porcine secretin to be of no value also had problems: it used only one injection rather than two or more, the hormone used was synthetic human secretin and not porcine secretin, relatively few children in the study, measuring changes that may not be sensitive to the effects of the hormone, and the failure to look at the subgroup of children who may have responded to a possible improvement in stomach problems due to the hormone.
The furor over secretin began when a three-year-old boy with autism received intravenous secretin prior to pancreatic testing.
Eight-year-old Jamie Powell has spoken for the first time since he was a baby after having an injection of secretin.
There are original contributions; the most recent at the time of this review was "A Double-Blind, Placebo-Controlled Trial of Secretin for the Treatment of Autistic Disorder.
The revolutionary secretin treatment was developed in America in the 1960s, but did not become available in Britain until last year - and then only on a restricted basis.