During acidification, H+ is transported into secondary lysosomes
by vacuolar type H+ adenosine triphosphatase (V-ATPase), and TCIRG1 encodes its a3 subunit.
The tracers are seen in coated pits, large coated vesicles, apical tubules, pale and dense multivesicular bodies, and secondary lysosomes
The degenerative alterations were characterized by sparse and degraded organelles, increased number of secondary lysosomes
or lysosomal residuals, frequently appearing crinophagy, lyric or pyknotic nuclei, and disrupted cell membranes and cellular structures (Figures 2-5).
These large cells have many cytoplasmic inclusions, such as phagosomes, secondary lysosomes, and residual bodies.
In some micrographs, large secondary lysosomes enclosing partly decomposed collagen fibrils were observed (Fig.
The collagen-containing secondary lysosomes observed in some of these cells suggest they may have a fibroclastic function, cleaning up the connective tissue compartment before new collagen synthesis starts.
2) was secreted into the sacs by a simple columnar epithelium with extensive rough endoplasmic reticulum and large secondary lysosomes containing lipofuscin and membrane fragments.
Columnar epithelial cells had a prominent, basally located pleomorphic nucleus and exceptionally large and abundant secondary lysosomes (Figs.