secondary lymphoid organ
, is also associated with accelerated atherosclerosis
In this DOCK2 knockout mouse, the function of activating Rac to mediate actin cyteskeleton, the lymphocyte migration function in response to stimuli with chemokines such as SLC, SDF-1, BLC, the homing function to secondary lymphoid organs
such as spleen, lymph nodes and Peyer's patches, and the function of emigrating mature thymic T cells into peripheral blood in response to stimulus with chemokine ELC are impaired, and as a result of this, immune responses are suppressed.
In most circumstances, if one looks hard enough, there is evidence that the virus is still probably replicating at very low levels in immune-privileged sites such as the brain and testes and in secondary lymphoid organs
According to current concepts of the normal Immoral immune system, all B lymphocytes arise from pluripotent stem cells in the bone marrow and then subsequently migrate to secondary lymphoid organs
such as lymph node follicles and Peyer patches in the gastrointestinal tract.
LECTURE 7 Secondary Lymphoid Organs
and Lymphocyte Trafficking
Moreover, aging miR-146a knockout animals develop frank tumors in the secondary lymphoid organs
, suggesting that miR-146a can function as a tumor suppressor in the context of the immune system.
Chemokines, or chemotactic cytokines, and their receptors have been discovered as essential and selective mediators in leukocyte migration to inflammatory sites and to secondary lymphoid organs