In an Iranian study by Monajemzadeh showed that secondary hemochromatosis
in patients with thalassemia composed the most prevalent diagnoses (17.
Most patients with primary hemochromatosis do not have involvement of the spleen; iron deposition in primary hemochromatosis occurs in the parenchymal cells of the liver (hepatocytes), hence splenic signal intensity usually is normal in these patients where as in secondary hemochromatosis
, iron deposition occurs in reticulo endothelial system (Kupffer cells and spleen).
Iron accumulation within the thyroid can be seen in patients with hemosiderosis either due to primary or secondary hemochromatosis
Prolonged and excessive iron ingestion and repeated blood transfusions that take place with hypoproliferative anemia and thalassemia may result in secondary hemochromatosis
Because patients with chronic liver diseases like hepatitis C may also harbor mutations associated with hereditary hemochromatosis, it may be impossible to distinguish hereditary from HCV-related or other causes of secondary hemochromatosis
without genetic testing.
The patient received frequent blood transfusions and monthly intravenous deferoxamine for secondary hemochromatosis
Multiple blood transfusions at that time were complicated by hepatitis C with cirrhosis and secondary hemochromatosis
, treated at home with twice weekly deferoxamine by subcutaneous central venous catheter.