secondary failure

sec·on·dar·y fail·ure

1. failure of the function of an organ as a result of antecedent pathology elsewhere;
2. decreasing responsiveness to a drug after an initial satisfactory response, usually occurring several months after initiation of treatment.

sec·on·dar·y fail·ure

(sekŏn-dar-ē fālyŭr)
1. Failure of function of an organ as a result of antecedent pathology elsewhere.
2. Decreasing responsiveness to a drug after an initial satisfactory response, usually occurring several months after initiation of treatment.
References in periodicals archive ?
Primary and secondary failure are the most common reasons for discontinuation of Entyvio for UC and CD; however, cumbersome MCO restrictions were also cited as a reason more often than other biologics.
Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
The failure of the firewalls separating different parts of the platform, a secondary failure since they were never designed to cope with an explosion, ignited the oil stores.
The failure of the firewalls separating different parts of the facility, a secondary failure since they were never designed to cope with an explosion, ignited the oil stores.
When circuit A is lost, the total load on circuit B is 16 amps, which will not cause a secondary failure.
She found that the character and distribution of skeletal effects was consistent with primary bone disease, but was more likely to be due to damage to embryonic sensory nerves arising in the neural crest, giving to secondary failure of bone and joint formation.
using algorithms to rebuild data), affecting performance and increasing the risk of a secondary failure or total loss of data.