secondary adrenal insufficiency


Also found in: Dictionary, Thesaurus, Legal.
Related to secondary adrenal insufficiency: tertiary adrenal insufficiency, Acute Adrenal Insufficiency

secondary adrenal insufficiency

Insufficient stimulation of the adrenal glands caused by failure of the pituitary gland to secrete adrenocorticotropic hormone. In this disorder, cortisol levels are reduced, but aldosterone secretion, which is governed by the renin-angiotensin-aldosterone system, is preserved. This differs from primary adrenal insufficiency or Addison disease in which the adrenal glands secrete neither cortisol nor aldosterone.
See also: insufficiency
References in periodicals archive ?
Patients with primary adrenal insufficiency do not produce cortisol during the 48- to 72-hour period; however, patients with secondary adrenal insufficiency have adequate responses to the test on the second or third day.
Hormonal investigations revealed hypopituitarism in the form of GH deficiency, central hypothyroidism, secondary adrenal insufficiency, secondary hypogonadism with hyperprolactinemia; the skull x- ray and standard sellar computed tomography (CT) were normal (9).
Our observation of the absence of increase in the F/E ratio after ACTH in patients with secondary adrenal insufficiency also argues against the inhibitory effect of ACTH on 11-HSD-2 activity, but in hypocortisolic patients.