second-line drug

second-line drug

Any therapeutic agent that is not the drug of choice, or the 1st normally used to treat a particular condition; in rheumatoid arthritis, 2nd-line agents are used when standard 'first-line' therapy–ie, anti-inflammatory agents and corticosteroids fail
References in periodicals archive ?
Losing the fluoroquinolones means we are losing a potent and minimally toxic option for second-line drug therapy.
We are using it for our hospice patients as a second-line drug.
Streptomycin is mainly used as a second-line drug for tuberculosis.
It can also be used as a second-line drug for absence as well as adjunct medication for tonic-clonic seizures and partial seizures.
Along with the Ministry of Health of Uzbekistan, and in accordance with WHO advice (8), Medecins Sans Frontieres investigated the efficacy, tolerability, and safety of the shortened regimen in Karakalpakstan, Uzbekistan (9), where rates of second-line drug resistance are high (1) and katG-mediated isoniazid resistance predominates.
Mvusi conceded that the Hain Line Probe Assay, version 2, would 'help greatly in reducing the waiting time for confirmatory first- and second-line drug susceptibility testing because the patient could then be switched to the appropriate regimen earlier'.
In August 2004 pemetrexed was approved as a second-line drug for local or metastatic non-small cell lung cancer.
Prevalence varied widely between countries, with resistance to any second-line drug found in nearly 44 percent of patients but ranging from 33 percent in Thailand to 62 percent in Latvia.
Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drug worldwide, 2000-2004.
They found that adding beta-blockers as the second-line drug, in combination with thiazide diuretics or calcium channel blockers, caused an additional blood pressure reduction.
The preferred second-line drug is atomoxetine (Strattera), a nonstimulant, highly specific norepinephrine reuptake inhibitor.
But I think that because glycemic control is important, the second-line drug still can be a sulfonylurea," said Dr.