A meta-analysis of head-to-head comparisons of second-generation antipsychotics
in the treatment of schizophrenia.
Use of a second-generation antipsychotic
drug was associated with a 3.
Appendix AS3: Predictive Margins of Second-Generation Antipsychotic
use among Continuously ([greater than or equal to] 10 Months/Year), Noncontinuously (<10 Months/ Year), and All (1-12 Months/Year) Medicaid-Enrolled U.
The second-generation antipsychotic
agents are not free of burdensome side effects, however.
The data showed that EVP-6124 had a clinically meaningful and statistically significant impact on patients' overall cognition - the trial's pre-specified primary endpoint - when taken in combination with second-generation antipsychotics
and as measured by the full CogState overall cognitive index, or "OCI" (p=0.
Risperdal Consta was the first long-acting injectable second-generation antipsychotic
to be licensed for the maintenance treatment of schizophrenia in patients currently stabilised with oral antipsychotics.
Villarreal said his personal practice is to reserve the second-generation antipsychotic
agents for the most severe cases, including those involving psychosis or severe dissociation, because of the significant metabolic and other side effects accompanying use of these drugs.
1) It has been suggested that clozapine should be positioned as a second-line treatment for first-episode schizophrenics who fail one trial of a second-generation antipsychotic
While the proportional use of second-generation antipsychotic
drugs was found to rise from 13 to 64 per cent during follow-up, the gap in life expectancy from age 20 years between patients with schizophrenia and the general population did not widen between 1996 and 2006.
In October 1997, Medi-Cal granted open access to three second-generation antipsychotic
medications: risperidone, olanzapine, and quetiapine.
drugs: mechanistically distinct or minor variants?
5%) were initiated on a second-generation antipsychotic