second messenger


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sec·ond mes·sen·ger

an intermediary molecule that is generated as a consequence of hormone-receptor interaction, for example, see adenosine 3',5'-cyclic monophosphate, guanosine 3',5'-cyclic monophosphate, calcium, inositide.

second messenger

a chemical substance inside a cell that carries information farther along the signal pathway from the internal part of a membrane-spanning receptor embedded in the cell membrane. It may be in the form of an enzyme's product or ion fluxes. Ca2+, nitric oxide, and cAMP are common examples.
References in periodicals archive ?
Binding of the neurotransmitter to the receptor activates G -proteins, which in turn induce the production of second messengers such as cyclic AMP (cAMP) that then activate kinases, ultimately resulting in the opening of ion channels in the cell's membrane.
mediated second messenger system causes saliva production in both the parotid and submandibular glands and enzymatic secretion in the parotid glands.
An initial neurotransmitter will activate the fast ion channel receptor, while a second or third neurotransmitter will activate the second messenger system that modifies the effect of the initial transmitter.
Reagents and assay kits segment is further divided into reporter gene assays, second messenger assays, cell growth assays, cell death assays and other assays.
Major types of cell based assays captured in the report include cell growth assays, cell death assays, second messenger assays and reporter gene assays.
Second Messenger presents complex psychopharmacologic concepts in a simple and readable format
Throughout the conference, the MaxCyte STX Scalable Transfection System will be on display and MaxCyte scientists and current scientific users will be available at Booth 812 to provide details about the latest use of transfected cells in protein production and functional, cell-based screening, including second messenger regulation, calcium flux, and automated electrophysiology assays.
Tenders are invited for Provision of Nucleotide Second Messenger Signaling in Bacteria.
The new study has revealed that analgesia mediated by inhibitors of the enzyme, soluble epoxide hydrolase (sEH), is dependent on a pain-mediating second messenger known as cyclic adenosinemonophosphate or cAMP.
The major second messenger pathways coupled to G proteins include cyclic AMP/protein kinase A, calcium/phospholipase C, beta-arrestin/MAPK and the Rho family GTPases, all of which can result in morphological changes easily detected by cellular impedance recording.
In the beginning of the multi-step growth process, BMPs bind to a cell and activate its receptors; then a second messenger is triggered, in this case Limk1.