8) Many other studies with small numbers of cases have also reported the findings of necrosis, reticulin fibrosis, (7) increased sea-blue histiocyte numbers, (9) dyserythropoiesis, gelatinous transformation, and lymphocytosis.
Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition including fat-emulsion sources: a clinicopathologic study of seven cases.
Pulmonary fibrosis and sea-blue histiocyte infiltration in a patient with primary myelofibrosis.
While not always statistically significant, certain features were more common in CVD than in the control group (Figure), including (1) abnormal bony trabeculae, (2) megaloblastoid changes in the erythroid lineage, (3) sea-blue histiocytes (SBHs), and (4) ALIP of the granulocytic lineage.
Sea-blue histiocytes, although relatively rare, have been reported in a variety of conditions ranging from the more commonly cited Niemann-Pick disease, to an effect of total parenteral nutrition including fat emulsions, to a variety of hematologic malignancies including non-Hodgkin lymphoma, light chain deposition disease, myeloproliferative neoplasms, and MDS.
Of these findings, only sea-blue histiocytes were unique to the CVD group (hematoxylin-eosin, original magnification 340 [A]; modified Wright-Giemsa, original magnifications31000 [B] and 3500 [C]; original magnification 3200 [D]).
Unusualpresentations of lymphoma: case 1, sea-blue histiocytes in non-Hodgkin's lymphoma.
Sea-blue histiocytes and Gaucher cells in bone marrow of patients with chronic myeloid leukaemia.
From this case study and others, we may conclude that apo E3[DELTA]149Leu causes a lipid-storage disease characterized by splenomegaly, splenic infiltration with foamy and sea-blue histiocytes
, and hypertriglyceridemia that may be unmasked following splenectomy.