scrapie


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scrap·ie

(skrap'ē, skrā'pē),
A communicable spongiform encephalopathy of the central nervous system of sheep and goats caused by a prion and characterized by a very long incubation period followed by pruritus, abnormalities of gait, and invariably death; it resembles Creutzfeldt-Jakob disease and kuru in humans.
[from scraping by affected animals against objects to relieve itching]

scrapie

/scra·pie/ (skra´pe) a prion disease occurring in sheep and goats, characterized by severe pruritus, debility, and muscular incoordination, ending in death.

scrapie

(skrā′pē, skrăp′ē)
n.
A fatal neurodegenerative disease of sheep and goats caused by a prion and marked by chronic itching and loss of muscular coordination.

scrapie

[skrā′pē]
the first of the prion diseases to be recognized, occurring in sheep and goats and characterized by severe pruritus, muscular incoordination, and increasing debility ending in death.
A prion-induced infection, which causes fatal neurologic degeneration in sheep and goats, who scrape themselves on rocks and other surrogate back-scratchers; the scrapie agents are transmissible spongiform encephalopathy agents, which integrate themselves into the cell membrane, possibly as replicable glycoproteins

scrap·ie

(skrā'pē)
A communicable spongiform encephalopathy of the central nervous system of sheep and goats caused by a prion; resembles Creutzfeldt-Jakob disease and kuru in humans.
[from scraping against objects by affected animals to relieve itching]

scrapie

A fatal nervous system disease of sheep featuring a SPONGIFORM ENCEPHALOPATHY. Scrapie is caused by a PRION and has an incubation period of 2 to 7 years.

scrapie

a disease of sheep, thought to be caused by PRIONS, in which the animal develops intense itching and increasing weakness, and eventually dies.

scrapie

an infectious, fatal, chronic disease of sheep and goats with clinical signs of pruritus, abnormalities of gait, recumbency and a long illness of about 6 months. A transmissible spongiform encephalopathy. The incubation period is at least 2 years. Susceptibility to scrapie is genetically determined and control programs are developed to select scrapie resistant sheep.

scrapie agent
scrapie is caused by an agent that acts like a virus but does not have the physical characteristics of one. Despite intensive study the true nature of the scrapie agent has not been defined; it is not a conventional virus or a viroid and current studies suggest that it may be a small-molecular-weight, 'self-replicating' basic protein for which the term prion has been proposed. The scrapie agent is of interest beyond its role as a rare pathogen for sheep in that it is a prototype of a new class of infectious agents responsible for a number of slow degenerative central nervous system diseases of humans and other animal species. See scrapie, prion, bovine spongiform encephalopathy, feline spongiform encephalopathy.
scrapie-associated fibrils
characteristic proteinaceous fibrils in the neurons of sheep with scrapie; the fibrils consist of membrane glycoprotein the DNA of which exists in the patient's brain cells. The glycoprotein accumulates because horizontally acquired scrapie agent induces transcription of the related host chromosomal gene and converts it to a polymerized proteinase-resistant fibrillar form.
scrapie eradication programs
most countries with scrapie have established scrapie eradication or scrapie monitoring schemes based on genotyping. According to the 2003 EU-Directive 2003/100/EC every member state has to establish a breeding program based on scrapie resistance.
scrapie eyelid test
the presence of the scrapie agent in lymphoid tissue allows its detection in the lymphoid tissue of the third eyelid in live sheep. This is in contrast to the BSE agent in cattle which does not occur in lymphoid tissue and for which there is no ante mortem test.
scrapie genotyping
susceptibility to scrapie is associated with polymorphisms in the ovine prion protein (PrP) gene at codons 136, 154 and 171. Genotyping can establish resistant sheep and genotype testing for susceptibility to scrapie is a key element of the scrapie eradication program.
References in periodicals archive ?
The most commonly used form of identification for goats is a scrapie tag.
Los haplotipos ARR y ARQ son considerados de resistencia y AHQ de resistencia intermedia, mientras que VRQ es un haplotipo de susceptibilidad para el scrapie (Baylis y Goldmann, 2004).
The classical scrapie specimen was of brain stem from a field suspect of the animal prion protein gene Prnp ARQ/ARQ genotype, and a brain stem specimen from an unaffected scrapie suspect of the same genotype was also supplied.
Developed by the Agricultural Research Service and Washington State University (WSU), the third-eyelid test has been used by APHIS and state veterinarians since 2002 as an official test to detect scrapie in sheep.
A new industry funded Scrapie monitoring scheme will be started in January 2009 and run by the Scottish Agricultural College (SAC).
Despite having a huge population, studies regarding genetic resistance to scrapie remain to be undertaken in Pakistani goats and sheep.
Scrapie was first recognized as a disease of sheep in Great Britain and other countries of Western Europe more than 250 years ago.
Two additional sequence variants, T137 and F141 [the latter is often referred to as NOR98 (14)], linked to so-called atypical scrapie cases (15) need to be considered because they are covered by the diagnostic probe for the A136 allele and can occur in considerable frequencies in specific breeds (15-18).
Many Welsh consumers are now faced with an anxious wait until more specific information regarding the report's actual findings on scrapie and the threat it may - or may not - pose to public health are revealed.
We improved the BSE and Scrapie Rapid Assay performance and achieved 100% sensitivity and 100% specificity in a recent trial on confirmed positive and negative samples at the Veterinary Laboratory Agency (Weybridge, England).
When a human or animal contracts a TSE--such as mad cow disease in bovines, Creutzfeldt-Jakob disease in humans, and scrapie in sheep--prions begin to twist into abnormal shapes and form clumps that kill brain cells, producing symptoms including dementia and leading to certain death.
Scrapie in sheep and goats, a fatal neurodegenerative disease, is a member of the family of transmissible spongiform encephalopathies (TSEs), which includes bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease in deer and elk, and Creutzfeldt-Jakob disease in humans.