Also found in: Wikipedia.
Atrophic fibrosis of the skin, hypoplasia of the nails, and palmoplantar keratoderma; associated with skin and gastrointestinal cancers; autosomal dominant inheritance.
[sclero- + G. tylōsis, the process of becoming callous]
an inherited condition of atrophic fibrosis of the skin. There is overgrowth of the nails and horny skin covering the palms of the hands and plantar surfaces of the feet. The disorder may be accompanied by cancer of the GI tract.