of class B expressed by osteoblastic cells are implicated in the uptake of cholesteryl ester and estradiol from LDL and HDL3.
Although controversial, there is evidence that cholesterol returning to the liver in HDL via the scavenger receptor
type 131 (SRB1) is preferentially used in the formation of biliary cholesterol that is excreted into the intestines.
The liver contains a receptor called scavenger receptor
B1 that acts to stimulate cholesterol uptake for processing and disposal.
class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.
Known as a scavenger receptor
, the protein binds to a variety of fat-beating molecules and has been previously associated with hardening of the arteries and heart disease.
In this new era of personalized medicine, it is now possible to more accurately determine if the healthy cholesterol fraction, HDL, and its partner protein, scavenger receptor
class B type I (SR-BI), affect risk for heart disease in men and women as well as hormonal and fertility outcomes in women.
Pivotal advance: Activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor
Massachusetts Institute of Technology (Cambridge, MA) has patented two distinct scavenger receptor
type proteins having high affinity for modified lipoproteins and other ligands, including HaSR-BI, an AcLDL and LDL binding scavenger receptor
, which is distinct from the type I and type II macrophage scavenger receptors
, and DNA encoding the receptor cloned from a variant of Chinese Hamster Ovary Cells, designated Var-261, and dSR-CI, a non-mammalian AcLDL binding scavenger receptor
having high ligand affinity and broad specificity, isolated from Drosophila melanogaster.
Members of the scavenger receptor
family, such as class A scavenger receptor
(SR-A), CD36, LOX-1, and scavenger receptor
B-I (SR-BI), recognize common ligands such as modified LDL, bacteria, and advanced glycation end products, and they are thought to affect the progression of atherosclerosis (11, 12).
Recent data suggest that the CD163 receptor of macrophages not only functions as a scavenger receptor
for the Hp-hemoglobin complex but also has an immunomodulatory action with pivotal antiinflammatory properties leading to the synthesis of IL-10, heme oxygenase, and bilirubin (35).
Recent findings demonstrated that complexes of Hb and multimeric Hp 2-2 exhibit higher functional affinity for the Hb scavenger receptor
CD163 on macrophages, which is an acute-phase-regulated transmembrane protein produced exclusively in monocytes (low production) and tissue macrophages (high production) (4).
1038/nbt1339)) lipid-conjugates of siRNAs were found to associate with circulating LDL and HDL particles and to mediate their tissue biodistribution and cellular uptake in a manner dependent on certain LDL and HDL receptors, the LDL receptor (LDL-R) and the scavenger receptor
class B, type 1 (SR-B1), respectively.