It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein
LAT) are not randomly distributed within the plasma membrane thus giving rise to lateral organization which affects signalling efficiency.
According to scientists from OSU and Oregon Health and Science University, finding ways to maintain or increase the effectiveness of this gene - called Grp1-associated scaffold protein
, or Grasp - could offer an important new avenue for human cancer therapies.
In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein
The center has discovered that B cell scaffold protein
with ankyrin repeats (BANK), a kind of adapter molecule, inhibits the immune response of the B cell.
Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein
mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system
The NYU-Poly scientists inserted the unstable exoinulinase (EI) protein into a thermophilic scaffold protein
, which is known for its stability and a propensity to protect less stable proteins.
The TSRI scientists wanted a way to design scaffold proteins
from scratch-proteins that would fit around their functional fragments more naturally, and would do a better job of stabilizing them.
Boehringer Ingelheim has brought 18 molecules to market and has many years of experience in multiple molecule classes such as monoclonal antibodies, recombinant proteins, interferons, enzymes, fusion molecules, novel scaffold proteins
and plasmid DNA.
Furthermore, high-titer platform technologies for new antibody mimetic formats such as scaffold proteins
and antibody fragments are available for the manufacture of customer products.
As the malaria parasite can only reproduce in its 'banana form', if we can target these scaffold proteins
in a vaccine or drug, we may be able to stop it reproducing and prevent malaria transmission entirely," he added.