Durable complete remission of metastatic sarcomatoid carcinoma
of the bladder with cisplatin and gemcitabine in an 80-year-old-man.
of the prostate: progression from adenocarcinoma associated with p53 over-expression.
Immunohistological differentiation between histological variants PAN-CYTOKERATIN ACTIN DESMIN Sarcomatoid carcinoma
Positive Positive, rarely Leiomyosarcoma Rarely positive Positive, extensively Lipoid urothelial CK 7, CK 20 Positive Negative carcinoma Our case Positive Negative (Liposarcomatoid variant) P63, CK5/6 S-100 Sarcomatoid carcinoma
Positive (up to 40%) Leiomyosarcoma Negative Lipoid urothelial Negative carcinoma Our case Negative Positive (Liposarcomatoid variant)
Surgery is suggested as the only recognized treatment for gallbladder sarcomatoid carcinoma
Actin and desmin are typically negative or weakly positive in sarcomatoid carcinoma
and carcinosarcoma of the urinary bladder.
of the Bladder (SCB) which consists of sarcomatous and carcinomatous components simultaneously are very rare variants of Transitional Cell Carcinoma (TCC).
When it does occur, its clinical features resemble those of sarcomatoid carcinoma
, and its biologic behavior is similar to that of malignant mesenchymal neoplasms.
On his 40th birthday, Winter's father, Michael Vinecki was diagnosed with sarcomatoid carcinoma
Sarcomatoid MM raises the differential diagnosis of sarcomatoid carcinoma
, malignant tumors with sarcomatoid features, and a variety of malignant sarcomas, including undifferentiated pleomorphic sarcoma (formerly malignant fibrous histiocytoma), osteosarcoma, and chondrosarcoma.
One case of sarcomatoid carcinoma
with biphasic histology exhibiting both carcinomatous and spindle cell components on immunohistochemistry revealed features of sarcoma with vimentin positivity (Fig.
Also leiomyosarcoma, sarcomatoid carcinoma
and rhabdomyosarcoma are malignant lesions which can be categorized in the differential diagnosis of IMT.