SAMe

(redirected from sameness)
Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

SAMe

(sam-ee) ,

Ademetionine

(trade name),

S-adenosylmethionine

(trade name), (trade name)

Classification

Therapeutic: antidepressants
Pregnancy Category: UK
Treatment of depressionHas also been used to manage:
  • osteoarthritis
  • fibromyalgia
  • liver disease
  • migraine headaches

Action

May aid in the production, activation, and metabolism of various amines, phospholipids, hormones, and neurotransmitters. May stimulate articular cartilage growth and repair.

Therapeutic effects

Decreased depression.
Anti-inflammatory and analgesic effects improve symptoms of osteoarthritis.

Pharmacokinetics

Absorption: Rapidly and extensively metabolized following oral administration.
Distribution: Unknown.
Metabolism and Excretion: Actively metabolized by the liver.
Half-life: 100 min.

Time/action profile (antidepressant action)

ROUTEONSETPEAKDURATION
PO (depression)1–2 wkunknownunknown
PO (osteoarthritis)30 daysunknownunknown

Contraindications/Precautions

Contraindicated in: Hypersensitivity; Bipolar disorder.
Use Cautiously in: Pregnancy, lactation, or children (safety not established); Bipolar disorder (can induce mania); Parkinson's disease (may worsen symptoms); Surgery (discontinue 2 weeks prior to elective procedures).

Adverse Reactions/Side Effects

Central nervous system

  • agitation
  • dizziness
  • mild insomnia
  • manic reactions (in patients with bipolar disorder)

Gastrointestinal

  • vomiting
  • diarrhea
  • flatulence

Interactions

Avoid use with antidepressants, meperidine, pentazocine, tramadol, and dextromethorphan (additive serotinergic effects may occur).May ↓ effectiveness of levodopa and worsen Parkinsonian symptoms.Should not be used concurrently with MAO inhibitors. Avoid use of SAMe within 2 wk of using a MAO inhibitor.Avoid use with natural products that increase serotonin levels such as l-tryptophan and St. John's wort.
Oral (Adults) Depression—200 mg once or twice daily, adjusted upward over 2 wk (range 400–1600 mg/day); Liver disorders—1200–1600 mg/day; Osteoarthritis—200 mg tid; Fibromyalgia—800 mg/day.

Availability

Tablets: 100 mg, 200 mg, 400 mgOTC

Nursing implications

Nursing assessment

  • Assess mental status for symptoms of depression prior to and periodically during therapy; advise patients with depression to be evaluated by a health care professional.
  • Assess symptoms of pain and fatigue prior to and periodically during therapy.

Potential Nursing Diagnoses

Ineffective coping (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • Oral: Administer on an empty stomach. Initial dose should be 200 mg once or twice daily to minimize GI disturbances. Dose may be adjusted upward over 1–2 wks depending on response and tolerance.

Patient/Family Teaching

  • Instruct patient to take SAMe as directed.
  • Advise patients to discontinue 2 weeks prior to elective surgical procedures.
  • Advise women to consult health care professional if pregnancy is planned or suspected or if breast feeding.

Evaluation/Desired Outcomes

  • Decrease in symptoms of depression.
  • Improvement in osteoarthritis symptoms.
References in periodicals archive ?
The Sameness Project's drive yesterday started at 10am at the Collegiate American School in Umm Suqiem.
Any potential generic version of COPAXONE should use the same gene expression markers and biological pathways to demonstrate sameness, as well as be evaluated via pre-clinical testing and full-scale, placebo-controlled clinical trials with measured clinical endpoints in patients with relapsing forms of multiple sclerosis to establish safety, efficacy and immunogenicity, concluded the company.
It also entails getting snapshots of the people and the meal and documentation of the recipes and the stories behind them, the moments of sameness between different people, so they can be put together in an online book at the end of the project," said Nahhas.
not settle for the safety of pretended sameness and the false security that sameness seems to offer.
Their study shows how drag performances before straight audiences emphasize both the sameness and difference of gay experience.
On the return trip home it dawned on me what it was--the sameness of many, many of the pistols on display.
The guessing ability may be related to the cognitive sameness and differences between Chinese and English people.
However, there was a significant lack of detail and nuance; a stock sameness pervaded.
Despite an increasing sameness in category offerings across trade classes, about 75% of people shop at five or more channels for consumer packaged goods (CPG).
23), I was prompted to think of the outstanding degree of sameness these leaders project for the Catholic in a diverse America.
Judgements of sameness in kind between members, and of numerical sameness of a member across time, merely project our conventions of individuation.
Here, then, is a theme of broader, more general interest than Byrne's narrow formulation by itself might suggest, and the theme on which the present scrutiny will focus: the assertion of transcendent sameness that recurs in such "identist" forms of pluralism.