A radiopharmaceutical used to treat bone pain caused by cancer metastases.
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The patient eventually became hormone refractory on complete hormone ablation and was started on Samarium-153 with a brief duration of PSA response.
The two new radioisotopes are rhenium-186 and samarium-153, Atomic Energy Organization of Iran Deputy Director Mohammad Qannadi said.
Radiologist Edward Silberstein of the University of Cincinnati Medical Center has been investigating a host of radionuclides with a natural affinity for bone, including samarium-153, strontium-89, and rhenium-186.
This device market encompasses devices for external beam radiation therapy (CyberKnife, Gamma Knife, electron emitting high energy linear accelerators, proton therapy machines etc), brachytherapy (seeds, applicators-afterloaders, and electronic brachytherapy) and systemic radiation therapy (Iodine-131, Samarium-153, Rhenium-186, Erbium-169, etc.
Percutaneous tumor curettage and interstitial delivery of samarium-153 coupled with kyphoplasty for treatment of vertebral metastases.
The study, "Use of Samarium-153 (QUADRAMET) to modulate phenotype and enhance killing of tumor cells" demonstrated that exposure to QUADRAMET resulted in up-regulation of surface molecules on cancer cells, including Fas (CD95), carcinoembryonic antigen (CEA), mucin 1 (MUC-1), intercellular adhesion molecule-1 (ICAM-1 or CD54), and major histocompatibility complex class I (MHC-1).