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salvage pathway

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salvage pathway
Oncology A popular term for a metabolic pathway that uses substrates other than the usual biosynthetic intermediates for a product–eg, 1. The salvage of free purines from the hydrolysis of nucleotides for the generation of new nucleotides, or 2. The 2º pathway of nucleotide synthesis, in which thymidylate is produced by thymidine kinase from thymidine, rather than the usual path in which deoxyuridylate is methylated by thymidylate synthetase into thymidylate, a pathway utilized by Pts with megaloblastic anemia. See Leucovorin 'rescue.'.


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The specific interaction between CLOCK and SIRT1 and the NAD+ salvage pathway also presents a starting point for drug development aimed at curbing cell dysfunction and death, thereby helping to solve major medical problems such as cancer and diabetes.
Since B and T lymphocytes cannot utilize the salvage pathway of purine biosynthesis, MPA is believed to provide a selective immunosuppressive effect on lymphocytes (Figure 1).
The rise in Nampt requires an intact mitochondrial NAD(+) salvage pathway as well as the mitochondrial NAD(+)-dependent deacetylases SIRT3 and SIRT4.
 
 
 
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