salvage pathway

sal·vage path·way

the use of preformed purine and pyrimidine bases to synthesize nucleotides.

salvage pathway

Oncology A popular term for a metabolic pathway that uses substrates other than the usual biosynthetic intermediates for a product–eg,
1. The salvage of free purines from the hydrolysis of nucleotides for the generation of new nucleotides, or.
2. The 2º pathway of nucleotide synthesis, in which thymidylate is produced by thymidine kinase from thymidine, rather than the usual path in which deoxyuridylate is methylated by thymidylate synthetase into thymidylate, a pathway utilized by Pts with megaloblastic anemia. See Leucovorin 'rescue. '.
References in periodicals archive ?
Forodesine hydrocloride is an orally-available transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells.
Adenosine deaminase, an enzyme of purine salvage pathway is found in human tissues.
This contract will support the further development of SOFIE~s family of proprietary imaging probes, known as 18F FAC, that measure the enzyme, dCK, which controls the rate of DNA production through the salvage pathway.
12 One of the most important salvage pathway that supplies ribose 5-phophate NADPH other glycolytic intermediates and end-products of cells is PPP.
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway.
In summary, we demonstrate that saponin-enriched fractions of CR BNO-1055 inhibit salvage pathway uptake of extracellular nucleosides most likely by impairing ENT-dependent transport and long-term cell proliferation.
Vitamer levels, stress Response, Enzyme activity and Gene regulation of Arabidopsis Lines mutant in the pyridoxine/pyridoxamine 5'phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) gene involed in the vitamin B6 salvage pathway.
Similar to what can be observed for isolated varicocele that may represent a salvage pathway for portal hypertension in patients with other unilateral portosystemic shunts in the triple testicular blood drainage [3], such variations may also explain asymmetric infection load in patients with S.
Emergency cesarean represents a salvage pathway for cases in which vaginal birth is no longer an option, so complications of this surgery should not be used in the evaluation of elective cesarean delivery.
Lymphocytes have a greater dependence on the de novo pathway than on the salvage pathway.