salvage pathway

sal·vage path·way

the use of preformed purine and pyrimidine bases to synthesize nucleotides.

salvage pathway

Oncology A popular term for a metabolic pathway that uses substrates other than the usual biosynthetic intermediates for a product–eg,
1. The salvage of free purines from the hydrolysis of nucleotides for the generation of new nucleotides, or.
2. The 2º pathway of nucleotide synthesis, in which thymidylate is produced by thymidine kinase from thymidine, rather than the usual path in which deoxyuridylate is methylated by thymidylate synthetase into thymidylate, a pathway utilized by Pts with megaloblastic anemia. See Leucovorin 'rescue. '.
References in periodicals archive ?
This contract will support the further development of SOFIE~s family of proprietary imaging probes, known as 18F FAC, that measure the enzyme, dCK, which controls the rate of DNA production through the salvage pathway.
This contract will support the further development of SOFIE's family of proprietary imaging probes, known as[18F]FAC, that measure the enzyme, dCK, which controls the rate of DNA production through the salvage pathway.
Radu, Nathanson and their colleagues found that an important nucleotide called deoxycytidine triphosphate (dCTP) is produced by two pathways, the de novo pathway and the nucleoside salvage pathway.
Vitamer levels, stress Response, Enzyme activity and Gene regulation of Arabidopsis Lines mutant in the pyridoxine/pyridoxamine 5'phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) gene involed in the vitamin B6 salvage pathway.
Emergency cesarean represents a salvage pathway for cases in which vaginal birth is no longer an option, so complications of this surgery should not be used in the evaluation of elective cesarean delivery.
Lymphocytes have a greater dependence on the de novo pathway than on the salvage pathway.
Bennett believes they provide a way for healthy cells to recycle DNA from dead ones, in " a salvage pathway for conserving DNA's building blocks.
Tumors use the salvage pathway to provide high rates of DNA replication for their uncontrolled growth of cells containing malignant instructions.
In the new study, Sassone-Corsi and his colleagues show that CLOCK works in balance with SIRT1 to direct activity in a cell pathway by which metabolic proteins send signals called the NAD+ salvage pathway.
Forodesine is an orally-available transition-state analog inhibitor of purine nucleoside phosphorylase (PNP), a purine salvage pathway enzyme that is essential for the proliferation of T-cells and B-cells.