salvage chemotherapy

sal·vage che·mo·ther·a·py

use of chemotherapy in a patient with recurrence of a malignancy following initial treatment, in hope of a cure or prolongation of life.
Synonym(s): salvage therapy (1)

salvage chemotherapy

A treatment modality consisting of high-dose chemotherapy and bone marrow transplantation for cancer patients who have “failed” one or more protocols. For instance, in Hodgkin lymphoma, 24% of those with long initial remissions survive > 11 years, and thus require further (salvage) therapy (e.g., ABVD—doxorubicin, bleomycin, vinblastine, dacarbazine). Salvage regimens include high-dose chemotherapy (3–10-fold greater than conventional dosage), and may be combined with autologous bone marrow, or peripheral stem cell transplantation. Salvage chemotherapy is problematic as the patients may already be in poor condition, e.g., with severe clinical deterioration; large, bulky, aggressive tumour masses; and multi-drug resistances. Salvage chemotherapy is used in NHL, small cell carcinoma, and Hodgkin lymphoma.

salvage chemotherapy

Oncology A treatment modality consisting of high-dose chemotherapy and BMT, for cancer Pts who have 'failed' one or more protocols. See Heroic therapy.
References in periodicals archive ?
First patient recently enrolled in a randomized Phase 3 trial evaluating gilteritinib vs salvage chemotherapy or comparing gilteritinib and salvage chemotherapy in patients with relapsed or refractory AML
Paclitaxel, ifosfamide, and nedaplatin (TIN) salvage chemotherapy for patients with advanced germ cell tumors.
Patients with relapsed B-ALL have few treatment options; only 30 percent respond to salvage chemotherapy.
The patient was treated with salvage chemotherapy and, on follow-up imaging, the nodal masses were noted to be much smaller, the hepatic metastases had cleared completely, the limbic encephalitis changes had resolved, and there was normalisationvw of tumour markers.
A 57-year-old man with relapsed non-Hodgkin's lymphoma (NHL) was admitted for salvage chemotherapy with dexamethasone, ara-C and cisplatin.
In the circumstances it is the trust's that even with diagnosis in January the recommendation would still been for Miss Hall to have an intensive salvage chemotherapy including high dose chemotherapy with peripheral stem cell rescue and radiotherapy the site of the reoccurrence.
All patients had prostate-specific antigen (PSA) progression, Eastern Cooperative Oncology Group scores of 0-2, and were about to begin initial or salvage chemotherapy and/or combination therapy.
Remarkable application of serum EBV EBER-1 in monitoring response of nasopharyngeal cancer patients to salvage chemotherapy.
This is the first set of data for second-line use that suggests elderly patients, like younger patients, tolerate and receive benefit from a salvage chemotherapy regimen," said Karen Kelly, M.
For NSGCTs, tumor markers may be followed; when tumor markers such as human chorionic gonadotropin or alpha-fetoprotein remain elevated, salvage chemotherapy is indicated.
and in a variety of treatment strategies, including combinations with front-line and salvage chemotherapy regimens and as part of autologous and allogeneic stem cell transplantation.
Salvage chemotherapy with 3 cycles of etoposide, methylprednisolone, cytarabine, and cisplatin (ESHAP) produced a partial response.