salsalate


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salsalate

 [sal´sah-lāt]
an ester formed from two molecules of salicylic acid, used in treatment of rheumatoid arthritis and osteoarthritis.

sal·sa·late

(sal'să-lāt),
A combination of two molecules of salicylic acid in ester linkage. The compound is hydrolyzed during and after absorption to salicylic acid that, like other salicylates, exerts analgesic and antiinflammatory effects.

salsalate

/sal·sa·late/ (sal´sah-lāt) a salicylate with analgesic, antipyretic, and anti-inflammatory actions; used in the treatment of osteoarthritis and rheumatoid arthritis.

sal·sa·late

(sal'să-lāt)
A combination of two molecules of salicylic acid in ester linkage.
Synonym(s): salicylsalicylic acid.

salsalate (sal´səlāt),

n brand names: Armigesic, Anaflex, Arthra-G, Mono-Gesic, Salflex, and Salsitab;
drug class: salicylate, nonnarcotic analgesic;
action: blocks formation of peripheral prostaglandins, which cause pain and inflammation; antipyretic action results from inhibition of hypothalamic heat-regulating center; does not inhibit platelet aggregation;
uses: treatment of mild to moderate pain or fever, including arthritis and juvenile rheumatoid arthritis.
References in periodicals archive ?
Experts discovered salsalate curbed tangled knots of toxic protein forming in cells - one of the hallmarks of Alzheimer's.
Stage 1 of TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) evaluated varying doses of salsalate in 108 participants with type 2 diabetes for 14 weeks.
To prevent cachexia we used salsalate, silibinin, melatonin, glutamate, and fish oil.
Salsalate has fewer side effects than aspirin or salicylate and is inexpensive to manufacture.
The nonacetylated salicylates, including salsalate, magnesium choline trisalicylate, and diflunisal, as well as several of the nonsalicylate NSAIDs, such as low-dose etodolac, low-dose ibuprofen, and nabumetone, are reportedly less toxic to the GI mucosa than the other NS-NSAIDs.
Chen recommends non-acetylated salicylates such as salsalate (Disalcid) or diflunisal (Dolobid) before jumping to prescription NSAIDs.
This entity appears to be more prevalent after salsalate administration, and is characterized by a state of euthyroidism associated with decreased serum concentration of total thyroxine, relative or absolute decreases in calculated free thyroxine index (FTI).
Shoelson is an internationally recognized expert in diabetes research and has authored several recent studies showing that salsalate - a prodrug form of salicylate with anti-inflammatory activity - improves glucose homeostasis in people living with type 2 diabetes.
8) or Salsalate salicylsalicylic acid (2000 Compressed)
Salicylate, in a form called salsalate, has also shown potential as a treatment for insulin-resistance and type 2 diabetes.
Lack of platelet effect with the aspirin analog, salsalate.