safrole


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Related to safrole: sassafras oil

saf·role

(saf'rōl),
The methylene ether of allyl pyrocatechol; contained in oil of sassafras, oil of camphor, and various other volatile oils; it is obtained chiefly from oil of camphor by fractional distillation; formerly used as a tonic and carminative; prolonged administration causes fatty degeneration.

safrole

Toxicology
An oily phenylpropene extracted from the root-bark or the fruit of sassafras (Sassafras albidum), as well as camphor and other volatile oils. Once used as a carminative, intestinal tonic, topical antiseptic and pediculoside, it is hepatotoxic, causing fatty degeneration, and is carcinogenic; it is listed by the FDA as unsafe.
References in periodicals archive ?
Belgium requires and enforces strong reporting requirements for the import and export of precursor chemicals (bulk pseudoephedrine, ephedrine, safrole oil, and benzyl methyl ketone), and the Belgian Federal Police have the lead role in enforcing these controls.
The doses needed to protect the rats from safrole were small and nontoxic -- 0.
Safrole, the main constituent, causes tumors in rats.
In order to combat this practice, the Ministry of Economic Affairs, Industrial Development Bureau serves as the regulatory agency for chemicals such as acetic anhydride, piperonal, safrole, piperidine, hydrogen chloride, and potassium permanganate.
Among aromatics with allyl, propenyl and/or methoxy side chains, safrole and asarone showed similar trypanocidal activity, safrole being a little bit more active than asarone.
Studies comparing repeated dosing for early postnatal, juvenile, adult time periods, or lifetime exposures exist for six mutagens [benzidine, diethylnitrosamine (DEN), 3-methylcholanthrene, safrole, urethane, and vinyl chloride; Tables 1, 2, 3; Supplementary Table S4 (http://ehp.
Criminal networks also use Cambodia to illegally produce and export natural safrole oil, which can be used as a precursor for MDMA (ecstasy).
parthenoxylon focused on the essential oils, including safrole, eugenol, and cinnamic aldehyde, isolated from the essential oil fraction (Cinnamon research group, 1965).
While usually not a final destination for international shipments of precursors, Belgium has surfaced as a transit zone for significant quantities of precursor chemicals including ephedrine/pseudoephedrine, safrole oil and BMK and the pre-precursor alpha- phenylacetoacetonitrile (APAAN).
Safrole, a constituent of the volatile oil in Herba Asari, has been shown to be carcinogenic to animal (Drew et al.
a) The chemicals classified as mutagenic were benzidine, benzo(a)pyrene, DEN, safrole, and vinyl chloride; the chemicals classified as not mutagenic were amitrole, diphenylhydantoin, ethylene thiourea, and polybrominated biphenyls.
Criminal networks, many of which are Asian and West African, also use Cambodia to illegally produce and export natural safrole oil, which can be used as a precursor for MDMA (ecstasy).